引用本文:
Yong DENG, Yu YANG, Hui JIN, Yu Guo ZHONG. Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives[J]. Chinese Chemical Letters,
2004, 15(10): 1173-1176.
Citation: Yong DENG, Yu YANG, Hui JIN, Yu Guo ZHONG. Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives[J]. Chinese Chemical Letters, 2004, 15(10): 1173-1176.
Citation: Yong DENG, Yu YANG, Hui JIN, Yu Guo ZHONG. Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives[J]. Chinese Chemical Letters, 2004, 15(10): 1173-1176.
Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives
摘要:
Based on the structure-activity relationships of RGD-containing peptides, a series of 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. All of them were first reported.Their structures were confirmed by spectral data and elemental analysis. Their ability to inhibit angiogenesis were evaluated in the chick embryo chorioallantoic membrane assay at 10-5 mol/L.Compounds 5b and 5e displayed obviously antiangiogenic activity.
English
Synthesis of Some Potential Antiangiogenic 1,3-Dihydro-1,3-dioxo 2H-isoindole Derivatives
Abstract:
Based on the structure-activity relationships of RGD-containing peptides, a series of 1,3-dihydro-1,3-dioxo-2H-isoindole derivatives were synthesized. All of them were first reported.Their structures were confirmed by spectral data and elemental analysis. Their ability to inhibit angiogenesis were evaluated in the chick embryo chorioallantoic membrane assay at 10-5 mol/L.Compounds 5b and 5e displayed obviously antiangiogenic activity.
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