Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

Xin CHEN Lin WANG Zhi Zhong ZHAO Xing Quan ZHANG Xiang Hong CHEN Hong Shan CHEN

引用本文: Xin CHEN,  Lin WANG,  Zhi Zhong ZHAO,  Xing Quan ZHANG,  Xiang Hong CHEN,  Hong Shan CHEN. Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines[J]. Chinese Chemical Letters, 2000, 11(7): 571-572. shu
Citation:  Xin CHEN,  Lin WANG,  Zhi Zhong ZHAO,  Xing Quan ZHANG,  Xiang Hong CHEN,  Hong Shan CHEN. Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines[J]. Chinese Chemical Letters, 2000, 11(7): 571-572. shu

Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

  • 基金项目:

    We acknowledge our thanks to the National Natural Science Foundation of China for the Financial support, Grant No. 39970868.

摘要: We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, Ii) can inhibit HIV-1 RT with IC50 20.0, 43.8, and 63.7 μM, respectively.

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  • 收稿日期:  2000-01-17
通讯作者: 陈斌, bchen63@163.com
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