引用本文:
Xin CHEN, Lin WANG, Zhi Zhong ZHAO, Xing Quan ZHANG, Xiang Hong CHEN, Hong Shan CHEN. Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines[J]. Chinese Chemical Letters,
2000, 11(7): 571-572.
Citation: Xin CHEN, Lin WANG, Zhi Zhong ZHAO, Xing Quan ZHANG, Xiang Hong CHEN, Hong Shan CHEN. Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines[J]. Chinese Chemical Letters, 2000, 11(7): 571-572.
Citation: Xin CHEN, Lin WANG, Zhi Zhong ZHAO, Xing Quan ZHANG, Xiang Hong CHEN, Hong Shan CHEN. Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines[J]. Chinese Chemical Letters, 2000, 11(7): 571-572.
Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines
摘要:
We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, Ii) can inhibit HIV-1 RT with IC50 20.0, 43.8, and 63.7 μM, respectively.
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关键词:
- Piperazine
- / phthalimide
- / HIV1-RT inhibitor
English
Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines
Abstract:
We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, Ii) can inhibit HIV-1 RT with IC50 20.0, 43.8, and 63.7 μM, respectively.
-
Key words:
- Piperazine
- / phthalimide
- / HIV1-RT inhibitor
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