引用本文:
Bin YANG, Zhen Kai DING, Zong Jin HAN, Qi Kai ZHANG. Synthesis of Salmon Calcitonin Analogs Using Fmoc-based Chemistry on MBHA Resins[J]. Chinese Chemical Letters,
1999, 10(7): 549-552.
Citation: Bin YANG, Zhen Kai DING, Zong Jin HAN, Qi Kai ZHANG. Synthesis of Salmon Calcitonin Analogs Using Fmoc-based Chemistry on MBHA Resins[J]. Chinese Chemical Letters, 1999, 10(7): 549-552.
Citation: Bin YANG, Zhen Kai DING, Zong Jin HAN, Qi Kai ZHANG. Synthesis of Salmon Calcitonin Analogs Using Fmoc-based Chemistry on MBHA Resins[J]. Chinese Chemical Letters, 1999, 10(7): 549-552.
Synthesis of Salmon Calcitonin Analogs Using Fmoc-based Chemistry on MBHA Resins
摘要:
Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins. Salmon calcitonin was modified by 1)cysteines at positions 1 and 7 were replaced by valine and alanine respectively to result in open chain analogs,2) the glycine at position 30 was replaced by alanine, D-alanine and sarcosine respectively, and 3) some residues were deleted besides the above two modifications. A modified two-step deprotection/cleavage procedure, in which a solvent of TFA/TMSBr/thioanisole/EDT/m-cresol combines with HF cleavage, was adopted in SPPS.
English
Synthesis of Salmon Calcitonin Analogs Using Fmoc-based Chemistry on MBHA Resins
Abstract:
Peptide analogs of salmon calcitonin (sCT) were synthesized by using Fmoc-based chemistry on MBHA resins. Salmon calcitonin was modified by 1)cysteines at positions 1 and 7 were replaced by valine and alanine respectively to result in open chain analogs,2) the glycine at position 30 was replaced by alanine, D-alanine and sarcosine respectively, and 3) some residues were deleted besides the above two modifications. A modified two-step deprotection/cleavage procedure, in which a solvent of TFA/TMSBr/thioanisole/EDT/m-cresol combines with HF cleavage, was adopted in SPPS.
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