引用本文:
Yi Yang Dong, Xue Qin REN, Ai Jin HUANG, Yi Liang SUN, Zeng Pei SUN. Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis[J]. Chinese Chemical Letters,
1998, 9(6): 565-568.
Citation: Yi Yang Dong, Xue Qin REN, Ai Jin HUANG, Yi Liang SUN, Zeng Pei SUN. Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis[J]. Chinese Chemical Letters, 1998, 9(6): 565-568.
Citation: Yi Yang Dong, Xue Qin REN, Ai Jin HUANG, Yi Liang SUN, Zeng Pei SUN. Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis[J]. Chinese Chemical Letters, 1998, 9(6): 565-568.
Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis
摘要:
Cyclodextrin-modified CZE was applied to the chiral separation of two basic drugs, i.e., esmolol and terazosin. Selector screening and concentration optimization experiments were performed. Resolution 3.1 for esmolol, 1.2 for terazosin were achieved when using 60 mmol/L γ-CD and 60 mmol/L DM-β-CD, respectively, in 50 mmol/L pH 2.5 sodium phosphate buffer.
English
Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis
Abstract:
Cyclodextrin-modified CZE was applied to the chiral separation of two basic drugs, i.e., esmolol and terazosin. Selector screening and concentration optimization experiments were performed. Resolution 3.1 for esmolol, 1.2 for terazosin were achieved when using 60 mmol/L γ-CD and 60 mmol/L DM-β-CD, respectively, in 50 mmol/L pH 2.5 sodium phosphate buffer.
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Key words:
- Capillary zone electrophoresis
- / Chiral separation
- / Cyclodextrin
- / Esmolol
- / Terazosin
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