引用本文:
齐传民, 陈万义, 王文军. 2,2-二取代-5-亚苄(糠)基环戊酮类化合物的合成及其生物活性[J]. 应用化学,
1998, 15(2): 35-38.
Citation: Qi Chuanmin, Chen Wanyi, Wang Wenjun. Synthesis and Biological Activity of 2,2-Disubstituted 5-Benzal(fural) Cyclopentanones[J]. Chinese Journal of Applied Chemistry, 1998, 15(2): 35-38.
Citation: Qi Chuanmin, Chen Wanyi, Wang Wenjun. Synthesis and Biological Activity of 2,2-Disubstituted 5-Benzal(fural) Cyclopentanones[J]. Chinese Journal of Applied Chemistry, 1998, 15(2): 35-38.
2,2-二取代-5-亚苄(糠)基环戊酮类化合物的合成及其生物活性
English
Synthesis and Biological Activity of 2,2-Disubstituted 5-Benzal(fural) Cyclopentanones
Abstract:
Eighteen substituted cyclopentanones containing cyclopentenyl were synthesized. Their chemical structures were confirmed by elemental analysis, IR and 1H NMR measurements. The anticancer activities of the compounds have been examined. Compounds 2l, 2e and 2r were found to be active against KB, HCT, A2780, and A549 tumors in vitro. Compounds 2b and 2d showed activity only against HCT tumor. Compound 2e showed some fungistatic activity against plant pathogens in vitro.
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Key words:
- benzal(fural) cyclopentanones
- / synthesis
- / anticancer
- / antifungal activity
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