Citation:
ZHUO Renxi, YE Dakeng, LIU Gaowei, LIU Zhenhua, WANG Xuan. CHEMOTHERAPEUTIC POLYMERS. THE SYNTHESIS OF POLYMERS CONTAINING 5-FLUOROURACIL IN THE MAIN CHAIN*[J]. Chinese Journal of Polymer Science,
1984, 2(1): 7-11.
CHEMOTHERAPEUTIC POLYMERS. THE SYNTHESIS OF POLYMERS CONTAINING 5-FLUOROURACIL IN THE MAIN CHAIN*
摘要:
1,3-Dialkyl-5-fluorouracil compounds and polymers containing 5-fluorouracil in the main chain were synthesized by the reaction of 5-fluorouracil with alkylbromidcs and polymethylene bromides respectively. The structures of the new compounds and polymers were confirmed by IR and NMR spectra as well as elemental analyses. The factors affecting the polycondensation, such as the temperature and time of the reaction were investigated. The anti-tumor activity of some of the 5-fluorouracil containing compounds and polymers were also measured.
English
CHEMOTHERAPEUTIC POLYMERS. THE SYNTHESIS OF POLYMERS CONTAINING 5-FLUOROURACIL IN THE MAIN CHAIN*
Abstract:
1,3-Dialkyl-5-fluorouracil compounds and polymers containing 5-fluorouracil in the main chain were synthesized by the reaction of 5-fluorouracil with alkylbromidcs and polymethylene bromides respectively. The structures of the new compounds and polymers were confirmed by IR and NMR spectra as well as elemental analyses. The factors affecting the polycondensation, such as the temperature and time of the reaction were investigated. The anti-tumor activity of some of the 5-fluorouracil containing compounds and polymers were also measured.
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