引用本文:
Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI. First Total Synthesis of (-)-4-0-(6'-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl Alcohol[J]. Chinese Chemical Letters,
1998, 9(8): 717-720.
Citation: Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI. First Total Synthesis of (-)-4-0-(6'-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl Alcohol[J]. Chinese Chemical Letters, 1998, 9(8): 717-720.
Citation: Zuo Sheng LIU, Chu Sheng HUANG, Jiong LAN, Yu Lin LI. First Total Synthesis of (-)-4-0-(6'-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl Alcohol[J]. Chinese Chemical Letters, 1998, 9(8): 717-720.
First Total Synthesis of (-)-4-0-(6'-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl Alcohol
摘要:
The reduction of 2,3-epoxy alcohol, prepared from the Sharpless asymmetric epoxidation, with the system of Ph3P, iodine, imidazole, 2,6-lutidine and water in Et20/CH3CN, gives a chiral secondary allylic alcohol in 94% yield and 92% e.e.. Using this reaction as the key step, we synthesized (-)-coniferyl alcohol derivative 1 starting from the geraniol through nine steps in an overall yield of 39%.
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关键词:
- coniferyl alcohol
- / synthesis
English
First Total Synthesis of (-)-4-0-(6'-hydroxy-7'(9')-dehydro-6',7'-dihydrogeranyl)-coniferyl Alcohol
Abstract:
The reduction of 2,3-epoxy alcohol, prepared from the Sharpless asymmetric epoxidation, with the system of Ph3P, iodine, imidazole, 2,6-lutidine and water in Et20/CH3CN, gives a chiral secondary allylic alcohol in 94% yield and 92% e.e.. Using this reaction as the key step, we synthesized (-)-coniferyl alcohol derivative 1 starting from the geraniol through nine steps in an overall yield of 39%.
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Key words:
- coniferyl alcohol
- / synthesis
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