引用本文:
廖全斌, 刘明国, 陈百玲, 丁明武. 3-苯基-噻吩并嘧啶-4-酮衍生物的合成及其抑菌活性[J]. 应用化学,
2010, 27(5): 533-538.
doi:
10.3724/SP.J.1095.2010.90454
Citation: LIAO Quan-Bin, LIU Ming-Guo, CHEN Bai-Ling, DING Ming-Wu. Synthesis and Bacteriostatic Activities of 3-Phenyl-thienopyrimidin-4-ones[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 533-538. doi: 10.3724/SP.J.1095.2010.90454
Citation: LIAO Quan-Bin, LIU Ming-Guo, CHEN Bai-Ling, DING Ming-Wu. Synthesis and Bacteriostatic Activities of 3-Phenyl-thienopyrimidin-4-ones[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 533-538. doi: 10.3724/SP.J.1095.2010.90454
3-苯基-噻吩并嘧啶-4-酮衍生物的合成及其抑菌活性
摘要:
利用三组分氮杂Wittig反应,以三氢环戊二烯并噻吩基磷亚胺、异氰酸苯酯和酚,合成了13种未见文献报道的2-芳氧基-3-苯基-3,5,6,7-四氢-4H-环戊二烯并[4,5]噻吩并[2,3-d]-嘧啶-4-酮衍生物,产率63%~78%。通过IR、1H NMR、MS和元素分析测试技术对目标化合物的结构进行了表征。抑菌试验显示,所合成的化合物对真菌(桔青霉菌)的抑制活性优于对细菌的抑制活性。
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关键词:
- 噻吩并嘧啶酮
- / 氮杂Wittig反应
- / 合成
- / 抑菌活性
English
Synthesis and Bacteriostatic Activities of 3-Phenyl-thienopyrimidin-4-ones
Abstract:
Thirteen new 2-aryloxy-3-phenyl-3, 5, 6, 7-tetrahydro-4H-cyclopenta[4, 5]thieno[2, 3-d]pyrimidin-4-ones were synthesized in 63%~78% yields via the aza-Wittig reaction of (4,5,6-trihydrocyclopentathiophen-2-ylimino) (triphenyl) phosphorane with phenyl iso-cyanate, and subsequent reaction with phenols. Their structures were confirmed by IR,1H NMR, MS and elemental analysis. The bacteriostatic activities of the new compounds were tested. The results show that bacteriostatic activities of the compounds against fungus (Penicillium citrinum Thom) are better than those against bacteria.
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Key words:
- thienopyrimidinone
- / aza-Wittig reaction
- / synthesis
- / bacteriostatic activity
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