引用本文:
Yu Fei SONG, Pin YANG, Leung SHEH. Synthesis of Some Novel 2,6-Dimethoxyhydroquinone-3-mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents[J]. Chinese Chemical Letters,
2000, 11(8): 667-670.
Citation: Yu Fei SONG, Pin YANG, Leung SHEH. Synthesis of Some Novel 2,6-Dimethoxyhydroquinone-3-mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents[J]. Chinese Chemical Letters, 2000, 11(8): 667-670.
Citation: Yu Fei SONG, Pin YANG, Leung SHEH. Synthesis of Some Novel 2,6-Dimethoxyhydroquinone-3-mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents[J]. Chinese Chemical Letters, 2000, 11(8): 667-670.
Synthesis of Some Novel 2,6-Dimethoxyhydroquinone-3-mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents
摘要:
This paper reports an ongoing study of the use of short chain peptides as carriers of a potential antitumor agents: 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). Three new peptide-DMQ-MA conjugates: DMQ-MA-arg-arg-ome, DMQ-MA-lys(cbz)-arg-ome, DMQ-MA-lys(cbz)-arg-arg-ome were synthesized by coupling protected amino acids in solution and the next conjugation was achieved by reacting with pentafluorophenyl ester of DMQ-MA in DMF, and further study on their ability to inhibit human pulmonary adenocarcinoma cell line (PC-9 cells) and oral epidermoid carcinoma cell line (KB) are investigating.
English
Synthesis of Some Novel 2,6-Dimethoxyhydroquinone-3-mercaptoacetyl-peptide Conjugates as Potential Antitumor Agents
Abstract:
This paper reports an ongoing study of the use of short chain peptides as carriers of a potential antitumor agents: 2,6-dimethoxyhydroquinone-3-mercaptoacetic acid (DMQ-MA). Three new peptide-DMQ-MA conjugates: DMQ-MA-arg-arg-ome, DMQ-MA-lys(cbz)-arg-ome, DMQ-MA-lys(cbz)-arg-arg-ome were synthesized by coupling protected amino acids in solution and the next conjugation was achieved by reacting with pentafluorophenyl ester of DMQ-MA in DMF, and further study on their ability to inhibit human pulmonary adenocarcinoma cell line (PC-9 cells) and oral epidermoid carcinoma cell line (KB) are investigating.
扫一扫看文章
计量
- PDF下载量: 1
- 文章访问数: 1426
- HTML全文浏览量: 29
下载:
