引用本文:
Hai Yang Liu, Kun Wang, Hai Yan Fu, Mao Lin Yuan, Hua Chen, Rui Xiang Li. Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions[J]. Chinese Chemical Letters,
2011, 22(6): 738-740.
doi:
10.1016/j.cclet.2010.12.048
Citation: Hai Yang Liu, Kun Wang, Hai Yan Fu, Mao Lin Yuan, Hua Chen, Rui Xiang Li. Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions[J]. Chinese Chemical Letters, 2011, 22(6): 738-740. doi: 10.1016/j.cclet.2010.12.048
Citation: Hai Yang Liu, Kun Wang, Hai Yan Fu, Mao Lin Yuan, Hua Chen, Rui Xiang Li. Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions[J]. Chinese Chemical Letters, 2011, 22(6): 738-740. doi: 10.1016/j.cclet.2010.12.048
Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions
摘要:
Amide, which is derived from proline and is inexpensive and air-stable, has been synthesized and characterized by 1H NMR,13C NMR, and MS.It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction.In the Pd/amide catalytic system, aryl bromides can be coupled with phenylboronic acid in ethanol/water(1:2;v/v)in excellent yields even with a low Pd loading of 0.01 mol%.Moreover, the scope of the reaction is broad, and a wide variety of functional groups are tolerant.
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关键词:
- Suzuki cross-coupling
- / Palladium catalyst
- / Aryl bromides
- / Amide
- / Water
English
Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions
Abstract:
Amide, which is derived from proline and is inexpensive and air-stable, has been synthesized and characterized by 1H NMR,13C NMR, and MS.It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction.In the Pd/amide catalytic system, aryl bromides can be coupled with phenylboronic acid in ethanol/water(1:2;v/v)in excellent yields even with a low Pd loading of 0.01 mol%.Moreover, the scope of the reaction is broad, and a wide variety of functional groups are tolerant.
-
Key words:
- Suzuki cross-coupling
- / Palladium catalyst
- / Aryl bromides
- / Amide
- / Water
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