SYNTHESIS OF ANALOGUES OF HUPERZINE A

Xu Chang HE Zhao Ying WANG Yun Long LI Zhen Rong XU Dong Lu BAI

引用本文: Xu Chang HE,  Zhao Ying WANG,  Yun Long LI,  Zhen Rong XU,  Dong Lu BAI. SYNTHESIS OF ANALOGUES OF HUPERZINE A[J]. Chinese Chemical Letters, 1993, 4(7): 597-600. shu
Citation:  Xu Chang HE,  Zhao Ying WANG,  Yun Long LI,  Zhen Rong XU,  Dong Lu BAI. SYNTHESIS OF ANALOGUES OF HUPERZINE A[J]. Chinese Chemical Letters, 1993, 4(7): 597-600. shu

SYNTHESIS OF ANALOGUES OF HUPERZINE A

  • 基金项目:

    This work was financially supported by a grant of the National Natural Science Foundation of China.The authors are greatly indebted to Dr.Xingzu Zhu and Mrs.Jie Feng in the Division of Pharmacology of the Institute for bio-assays.

摘要: A new Lycopodium alkaloid huperzine A (1) possesses a potent inhibitory activity of acetylcholinesterase.Six structurally simplified analogues of huperzine A, compound 6, 7, 8, 12,13 and 15, were prepared and the inhibitory activities were evaluated.

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  • 收稿日期:  1993-02-19
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