引用本文:
Ai Ming Yu, Hua Zheng YANG, Zhen Pu ZHANG. Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J]. Chinese Chemical Letters,
1998, 9(2): 139-142.
Citation: Ai Ming Yu, Hua Zheng YANG, Zhen Pu ZHANG. Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J]. Chinese Chemical Letters, 1998, 9(2): 139-142.
Citation: Ai Ming Yu, Hua Zheng YANG, Zhen Pu ZHANG. Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils[J]. Chinese Chemical Letters, 1998, 9(2): 139-142.
Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils
摘要:
A general method for the solid phase synthesis of hydro-uracils and thiouracils is de-scribed. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Prepa-ration of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosys-tem Ⅱ D1 protein inhibitors.
English
Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils
Abstract:
A general method for the solid phase synthesis of hydro-uracils and thiouracils is de-scribed. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Prepa-ration of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosys-tem Ⅱ D1 protein inhibitors.
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