引用本文:
Chao Jie WANG, Jian Hong WANG, Ying GAN, Zhi Yong CHEN, Gang Jun DU, Jin ZHAO. Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine[J]. Chinese Chemical Letters,
2006, 17(10): 1301-1304.
Citation: Chao Jie WANG, Jian Hong WANG, Ying GAN, Zhi Yong CHEN, Gang Jun DU, Jin ZHAO. Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine[J]. Chinese Chemical Letters, 2006, 17(10): 1301-1304.
Citation: Chao Jie WANG, Jian Hong WANG, Ying GAN, Zhi Yong CHEN, Gang Jun DU, Jin ZHAO. Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine[J]. Chinese Chemical Letters, 2006, 17(10): 1301-1304.
Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine
摘要:
A series of novel antitumor agents-the solanesylpiperazinotriamine derivatives were designed and synthesized, their structures were confirmed by IR, 1H-NMR, MS, and element analysis. The preliminary tests showed that at low micromolar concentrations these compounds exhibited obvious toxicity on tumor cells in vitro, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations they also evidently enhanced the curative effect of vincristine.
English
Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine
Abstract:
A series of novel antitumor agents-the solanesylpiperazinotriamine derivatives were designed and synthesized, their structures were confirmed by IR, 1H-NMR, MS, and element analysis. The preliminary tests showed that at low micromolar concentrations these compounds exhibited obvious toxicity on tumor cells in vitro, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations they also evidently enhanced the curative effect of vincristine.
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Key words:
- Solanesylpiperazinotriamine
- / antitumor activity
- / synergistic effect
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