引用本文:
程青芳, 许兴友, 王启发, 林俏, 刘望军, 杨绪杰. 超声波辐射下异阿魏酸对氯苯酚酯的一步合成[J]. 应用化学,
2010, 27(5): 618-620.
doi:
10.3724/SP.J.1095.2010.90527
Citation: CHENG Qing-Fang, XU Xing-You, WANG Qi-Fa, LIN Qiao, LIU Wang-Jun, YANG Xu-Jie. One-step Synthesis of 4-Chlorophenyl Isoferulate under Ultrasonic Irradiation[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 618-620. doi: 10.3724/SP.J.1095.2010.90527
Citation: CHENG Qing-Fang, XU Xing-You, WANG Qi-Fa, LIN Qiao, LIU Wang-Jun, YANG Xu-Jie. One-step Synthesis of 4-Chlorophenyl Isoferulate under Ultrasonic Irradiation[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 618-620. doi: 10.3724/SP.J.1095.2010.90527
超声波辐射下异阿魏酸对氯苯酚酯的一步合成
English
One-step Synthesis of 4-Chlorophenyl Isoferulate under Ultrasonic Irradiation
Abstract:
4-Chlorophenyl isoferulate was synthesized in one-step from isoferulic acid and 4-chlorophenol without the protection of the hydroxyl of isoferulic acid in the presence of 4-dimethylpyridine(DMAP) as catalyst and dicyclohexylcarbodiimide(DCC) as dehydrating agent under ultrasonic irradiation at room temperature. When reactants were mixed in a n(isoferulic acid):n(4-chlorophenol):n(DCC):n(DMAP)=1:1.2:1.2:0.1, and exposed to ultrasonic irradiation for 2.5 h, the yield was 76.2%. The structure of the product was confirmed by elemental analysis, 1H NMR and IR. This method avoids the long reaction time and increases the yield compared with traditional synthetic method.
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