引用本文:
洪珊珊, 胡延维, 乔春华. 5-[β-(2-羟苯基)丙炔酰胺基]-5-去氧腺苷的合成[J]. 应用化学,
2010, 27(5): 523-527.
doi:
10.3724/SP.J.1095.2010.90345
Citation: HONG Shan-Shan, HU Yan-Wei, QIAO Chun-Hu. Synthesis of 5-[β-(2-Hydroxylphenyl) propiolylamic]-5-deoxyadenosine[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 523-527. doi: 10.3724/SP.J.1095.2010.90345
Citation: HONG Shan-Shan, HU Yan-Wei, QIAO Chun-Hu. Synthesis of 5-[β-(2-Hydroxylphenyl) propiolylamic]-5-deoxyadenosine[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 523-527. doi: 10.3724/SP.J.1095.2010.90345
5-[β-(2-羟苯基)丙炔酰胺基]-5-去氧腺苷的合成
English
Synthesis of 5-[β-(2-Hydroxylphenyl) propiolylamic]-5-deoxyadenosine
Abstract:
To develop a novel inhibitor of Mycobacterium tuberculosis,a new compound 5-[β-(2-hydroxylphenyl)propynoylamic]-5-deoxyadenosine was synthesized from the starting material of 2-iodine phenol via a series of reactions such as Sonogashira and condensation reactions.The experimental conditions were optimized.The structure of the compound was determined by 1H NMR,13C NMR,IR and LC/MS.
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Key words:
- MbtA
- / MbtB
- / inhibitor
- / nucleoside compounds
- / synthesis
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