液滴微流控技术在生物医学中的应用进展

引用本文: 闫嘉航, 赵磊, 申少斐, 马超, 王进义. 液滴微流控技术在生物医学中的应用进展[J]. 分析化学, 2016, 44(4): 562-568. doi: 10.11895/j.issn.0253-3820.160144 shu

Citation: YAN Jia-Hang, ZHAO Lei, SHEN Shao-Fei, MA Chao, WANG Jin-Yi. Application Progress of Droplet-based Microfluidics in Biomedicine[J]. Chinese Journal of Analytical Chemistry, 2016, 44(4): 562-568. doi: 10.11895/j.issn.0253-3820.160144 shu

液滴微流控技术在生物医学中的应用进展

闫嘉航 ^1, ,
赵磊 ^2, ,
申少斐 ^1, ,
马超 ^2, ,
王进义 ^{1,2,
,}

1.
¹ 西北农林科技大学理学院, 杨凌 712100;
2.
² 西北农林科技大学动物医学院, 杨凌 712100

通讯作者: 王进义

基金项目:
本文系国家自然科学基金(Nos.21375106,21175107)项目资助 (Nos.21375106,21175107)

摘要: 液滴微流控是微流控芯片领域的一个重要分支,由于其诸多独特优势而得到了广泛的应用与研究。本文将概述液滴微流控的特点和基本原理,同时对近年来其在生物医学中的应用进行了简要综述,并展望了液滴微流控技术的发展前景。

关键词:

微流控
/ 液滴
/ 药物传递
/ 综述

English

Application Progress of Droplet-based Microfluidics in Biomedicine

1.
¹ College of Science, Northwest A & F University, Yangling 712100, China;
2.
² College of Veterinary Medicine, Northwest A & F University, Yangling 712100, China

Corresponding author: 王进义

Received Date: 18 February 2016
Fund Project:
本文系国家自然科学基金(Nos.21375106,21175107)项目资助

Abstract: Droplet-based microfluidics is one of the important branches of microfluidics. On account of its various unique advantages, it has been extensively applied and studied. In this review, we introduced the characteristics and the fundamentals of the droplet-based microfluidics. Meanwhile, its recent applications in biomedicine were reviewed. At last, the development of the droplet-based microfluidics was prospected.

Key words:

Microfluidics
/ Droplet
/ Drug-delivery
/ Review

1. [1]
  1 Pit A M, Duits M H G, Mugele F. Sensor. Actuat. B-Chem., 1990, 1(1-6):244-2481 Pit A M, Duits M H G, Mugele F. Sensor. Actuat. B-Chem., 1990, 1(1-6):244-248
2. [2]
  2 Di Carlo D, Aghdam N, Lee L P. Anal. Chem., 2006, 78(14):4925-49302 Di Carlo D, Aghdam N, Lee L P. Anal. Chem., 2006, 78(14):4925-4930
3. [3]
  3 Weigl B, Domingo G, LaBarre P, Gerlach J. Lab Chip, 2008, 8(12):1999-20143 Weigl B, Domingo G, LaBarre P, Gerlach J. Lab Chip, 2008, 8(12):1999-2014
4. [4]
  4 Rios A, Zougagh M, Avila M. Anal. Chim. Acta, 2012, 740:1-114 Rios A, Zougagh M, Avila M. Anal. Chim. Acta, 2012, 740:1-11
5. [5]
  5 Yan Y J, Boey D, Ng L T, Gruber J, Bettiol A, Thakor N V, Chen C H. Biosens. Bioelectron., 2016, 77:428-4345 Yan Y J, Boey D, Ng L T, Gruber J, Bettiol A, Thakor N V, Chen C H. Biosens. Bioelectron., 2016, 77:428-434
6. [6]
  6 LI Song-Jing, ZENG Wen. Chin. Hydrau. Pneu., 2013,(6):13-23 李松晶, 曾文. 液压与气动, 2013,(6):13-236 LI Song-Jing, ZENG Wen. Chin. Hydrau. Pneu., 2013,(6):13-23 李松晶, 曾文. 液压与气动, 2013,(6):13-23
7. [7]
  7 SONG Wen-Bin, DONG Zhao-Qing, REN Ji-Cun. J. Anal. Sci., 2011, 27(1):106-112 宋文斌, 董朝青, 任吉存. 分析科学学报, 2011, 27(1):106-1127 SONG Wen-Bin, DONG Zhao-Qing, REN Ji-Cun. J. Anal. Sci., 2011, 27(1):106-112 宋文斌, 董朝青, 任吉存. 分析科学学报, 2011, 27(1):106-112
8. [8]
  8 Somaweera H, Ibraguimov A, Pappas D. Anal. Chim. Acta, 2016, 907:7-178 Somaweera H, Ibraguimov A, Pappas D. Anal. Chim. Acta, 2016, 907:7-17
9. [9]
  9 Leman M, Abouakil F, Griffiths A D, Tabeling P. Lab Chip, 2015, 15(3):753-7659 Leman M, Abouakil F, Griffiths A D, Tabeling P. Lab Chip, 2015, 15(3):753-765
10. [10]
  10 Kasule J S, Maddala J, Mobed P, Rengaswamy R. Comput. Chem. Eng., 2016, 85:94-10410 Kasule J S, Maddala J, Mobed P, Rengaswamy R. Comput. Chem. Eng., 2016, 85:94-104
11. [11]
  11 Chen A F, Huang H X. J. Phys. Chem. C., 2016, 120(3):1556-156111 Chen A F, Huang H X. J. Phys. Chem. C., 2016, 120(3):1556-1561
12. [12]
  12 Du G S, Fang Q, Den Toonder J M J. Anal. Chim. Acta, 2016, 903:36-5012 Du G S, Fang Q, Den Toonder J M J. Anal. Chim. Acta, 2016, 903:36-50
13. [13]
  13 Choi K, Im M, Choi J M, Choi Y K. Microfluid. Nanofluid., 2012, 12(6):821-82713 Choi K, Im M, Choi J M, Choi Y K. Microfluid. Nanofluid., 2012, 12(6):821-827
14. [14]
  14 Huebner A M, Abell C, Huck W T S, Baroud C N, Hollfelder F. Anal. Chem., 2011, 83(4):1462-146814 Huebner A M, Abell C, Huck W T S, Baroud C N, Hollfelder F. Anal. Chem., 2011, 83(4):1462-1468
15. [15]
  15 Elani Y, deMello A J, Niu X Z, Ces O. Lab Chip, 2012, 12(18):3514-352015 Elani Y, deMello A J, Niu X Z, Ces O. Lab Chip, 2012, 12(18):3514-3520
16. [16]
  16 Rosenfeld L, Lin T, Derda R, Tang S K Y. Microfluid. Nanofluid., 2014, 16(5):921-93916 Rosenfeld L, Lin T, Derda R, Tang S K Y. Microfluid. Nanofluid., 2014, 16(5):921-939
17. [17]
  17 Miller O J, El Harrak A, Mangeat T, Baret J C, Frenz L, El Debs B, Mayot E, Samuels M L, Rooney E K, Dieu P, Galvan M, Link D R, Griffiths A D. P. Natl. Acad. Sci. USA, 2012, 109(2):378-38317 Miller O J, El Harrak A, Mangeat T, Baret J C, Frenz L, El Debs B, Mayot E, Samuels M L, Rooney E K, Dieu P, Galvan M, Link D R, Griffiths A D. P. Natl. Acad. Sci. USA, 2012, 109(2):378-383
18. [18]
  18 Liu Y G, Banerjee A, Papautsky I. Microfluid. Nanofluid, 2014, 17(2):295-30318 Liu Y G, Banerjee A, Papautsky I. Microfluid. Nanofluid, 2014, 17(2):295-303
19. [19]
  19 Joensson H N, Svahn H A. Angew. Chem. Int. Ed., 2012, 51(49):12176-1219219 Joensson H N, Svahn H A. Angew. Chem. Int. Ed., 2012, 51(49):12176-12192
20. [20]
  20 JIA Peng-Fei, JIANG Ke-Ming, LIU Cong, ZHOU Wu-Ping, ZHANG Tao, ZHANG Zhi-Qiang, LI Hai-Wen. Chem. Res. Appl., 2015, 27(8):1097-1103 贾朋飞, 蒋克明, 刘聪, 周武平, 张涛, 张志强, 黎海文. 化学研究与应用, 2015, 27(8):1097-110320 JIA Peng-Fei, JIANG Ke-Ming, LIU Cong, ZHOU Wu-Ping, ZHANG Tao, ZHANG Zhi-Qiang, LI Hai-Wen. Chem. Res. Appl., 2015, 27(8):1097-1103 贾朋飞, 蒋克明, 刘聪, 周武平, 张涛, 张志强, 黎海文. 化学研究与应用, 2015, 27(8):1097-1103
21. [21]
  21 Huebner A, Sharma S, Srisa-Art M, Hollfelder F, Edel J B, Demello A J. Lab Chip, 2008, 8(8):1244-125421 Huebner A, Sharma S, Srisa-Art M, Hollfelder F, Edel J B, Demello A J. Lab Chip, 2008, 8(8):1244-1254
22. [22]
  22 Rakszewska A, Tel J, Chokkalingam V, Huck W T S. Npg. Asia. Mater., 2014, 6:e13322 Rakszewska A, Tel J, Chokkalingam V, Huck W T S. Npg. Asia. Mater., 2014, 6:e133
23. [23]
  23 Wang Y L, Zhao L, Tian C, Ma C, Wang J Y. Anal. Methods-UK, 2015, 7(23):10040-1005123 Wang Y L, Zhao L, Tian C, Ma C, Wang J Y. Anal. Methods-UK, 2015, 7(23):10040-10051
24. [24]
  24 Song H, Tice J D, Ismagilov R F. Angew. Chem. Int. Ed., 2003, 42(7):768-77224 Song H, Tice J D, Ismagilov R F. Angew. Chem. Int. Ed., 2003, 42(7):768-772
25. [25]
  25 Kaler K V I S, Prakash R. Sensors-Basel, 2014, 14(12):23283-2330625 Kaler K V I S, Prakash R. Sensors-Basel, 2014, 14(12):23283-23306
26. [26]
  26 ZHAO Shu-Fang, BAI Lin, FU Yu-Hang, JIN Yong, CHENG Yi. Chem. Ind. Eng. Pro., 2015, 34(3):593-616 赵述芳, 白琳, 付宇航, 金涌, 程易. 化工进展, 2015, 34(3):593-61626 ZHAO Shu-Fang, BAI Lin, FU Yu-Hang, JIN Yong, CHENG Yi. Chem. Ind. Eng. Pro., 2015, 34(3):593-616 赵述芳, 白琳, 付宇航, 金涌, 程易. 化工进展, 2015, 34(3):593-616
27. [27]
  27 Gu H, Duits M H G, Mugele F. Int. J. Mol. Sci., 2011, 12(4):2572-259727 Gu H, Duits M H G, Mugele F. Int. J. Mol. Sci., 2011, 12(4):2572-2597
28. [28]
  28 Beatus T, Bar-Ziv R H, Tlusty T. Phys. REP., 2012, 516(3):103-14528 Beatus T, Bar-Ziv R H, Tlusty T. Phys. REP., 2012, 516(3):103-145
29. [29]
  29 Thorsen T, Roberts R W, Arnold F H, Quake S R. Phys. Rev. Lett., 2001, 86(18):4163-416629 Thorsen T, Roberts R W, Arnold F H, Quake S R. Phys. Rev. Lett., 2001, 86(18):4163-4166
30. [30]
  30 Anna S L, Bontoux N, Stone H A. Appl. Phys. Lett., 2003, 82(3):364-36630 Anna S L, Bontoux N, Stone H A. Appl. Phys. Lett., 2003, 82(3):364-366
31. [31]
  31 Dreyfus R, Tabeling P, Willaime H. Phys. Rev. Lett., 2003, 90(14):1450531 Dreyfus R, Tabeling P, Willaime H. Phys. Rev. Lett., 2003, 90(14):14505
32. [32]
  32 Cramer C, Fischer P, Windhab E J. Chem. Eng. Sci., 2004, 59(15):3045-305832 Cramer C, Fischer P, Windhab E J. Chem. Eng. Sci., 2004, 59(15):3045-3058
33. [33]
  33 Baroud C N, Gallaire F, Dangla R. Lab Chip, 2010, 10(16):2032-204533 Baroud C N, Gallaire F, Dangla R. Lab Chip, 2010, 10(16):2032-2045
34. [34]
  34 Pit A M, Duits M H G, Mugele F. Micromachines-Basel, 2015, 6(11):1768-179334 Pit A M, Duits M H G, Mugele F. Micromachines-Basel, 2015, 6(11):1768-1793
35. [35]
  35 Fan S K, Hsieh T H, Lin D Y. Lab Chip, 2009, 9(9):1236-124235 Fan S K, Hsieh T H, Lin D Y. Lab Chip, 2009, 9(9):1236-1242
36. [36]
  36 Fan S K, Hsu Y W, Chen C H. Lab Chip, 2011, 1(15):2500-250836 Fan S K, Hsu Y W, Chen C H. Lab Chip, 2011, 1(15):2500-2508
37. [37]
  37 Brown C V, McHale G, Trabi C L. Langmuir, 2015, 31(3):1011-101637 Brown C V, McHale G, Trabi C L. Langmuir, 2015, 31(3):1011-1016
38. [38]
  38 Nejad H, Hoorfar M. Microfluid Nanofluid, 2015, 18(3):483-49238 Nejad H, Hoorfar M. Microfluid Nanofluid, 2015, 18(3):483-492
39. [39]
  39 Banerjee A, Noh J H, Liu Y G, Rack P D, Papautsky I. Micromachines-Basel, 2015, 6(2):172-18539 Banerjee A, Noh J H, Liu Y G, Rack P D, Papautsky I. Micromachines-Basel, 2015, 6(2):172-185
40. [40]
  40 MacDonald M P, Spalding G C, Dholakia K. Nature, 2003, 426(6965):421-42440 MacDonald M P, Spalding G C, Dholakia K. Nature, 2003, 426(6965):421-424
41. [41]
  41 Chen K Y, Lee A T, Hung C C, Huang J S, Yang Y T. Nano. Lett., 2013, 13(9):4118-412241 Chen K Y, Lee A T, Hung C C, Huang J S, Yang Y T. Nano. Lett., 2013, 13(9):4118-4122
42. [42]
  42 Park S Y, Wu T H, Chen Y, Teitell M A, Chiou P Y. Lab Chip, 2011, 11(6):1010-101242 Park S Y, Wu T H, Chen Y, Teitell M A, Chiou P Y. Lab Chip, 2011, 11(6):1010-1012
43. [43]
  43 Chou W L, Lee P Y, Yang C L, Huang W Y, Lin Y S. Micromachines-Basel, 2015, 6(9):1249-127143 Chou W L, Lee P Y, Yang C L, Huang W Y, Lin Y S. Micromachines-Basel, 2015, 6(9):1249-1271
44. [44]
  44 Zhu Y, Fang Q. Anal. Chim. Acta, 2013, 787:24-3544 Zhu Y, Fang Q. Anal. Chim. Acta, 2013, 787:24-35
45. [45]
  45 MA Chao, SHEN Shao-Fei, ZHAO Lei, WANG Jin-Yi. J. Instr. Anal., 2015, 34(3):246-256 马超, 申少斐, 赵磊, 王进义. 分析测试学报, 2015, 34(3):246-25645 MA Chao, SHEN Shao-Fei, ZHAO Lei, WANG Jin-Yi. J. Instr. Anal., 2015, 34(3):246-256 马超, 申少斐, 赵磊, 王进义. 分析测试学报, 2015, 34(3):246-256
46. [46]
  46 Choi J W, Kim G J, Lee S, Kim J, deMello A J, Chang S I. Biosens. Bioelectron., 2015, 67:497-50246 Choi J W, Kim G J, Lee S, Kim J, deMello A J, Chang S I. Biosens. Bioelectron., 2015, 67:497-502
47. [47]
  47 Zeng Y, Novak R, Shuga J, Smith M T, Mathies R A. Anal. Chem., 2010, 82(8):3183-319047 Zeng Y, Novak R, Shuga J, Smith M T, Mathies R A. Anal. Chem., 2010, 82(8):3183-3190
48. [48]
  48 Zeng Y, Wang T Y. Anal. Bioanal. Chem., 2013, 405(17):5743-575848 Zeng Y, Wang T Y. Anal. Bioanal. Chem., 2013, 405(17):5743-5758
49. [49]
  49 Kim J, Khan M, Park S Y. ACS. Appl. Mater. Inter., 2013, 5(24):13135-1313949 Kim J, Khan M, Park S Y. ACS. Appl. Mater. Inter., 2013, 5(24):13135-13139
50. [50]
  50 Piao Y X, Han D J, Azad M R, Park M, Seo T S. Biosens. Bioelectron., 2015, 65:220-22550 Piao Y X, Han D J, Azad M R, Park M, Seo T S. Biosens. Bioelectron., 2015, 65:220-225
51. [51]
  51 Wu S Z, Zhou Z Y, Xu L R, Su B, Fang Q. Biosens. Bioelectron., 2014, 53:148-15351 Wu S Z, Zhou Z Y, Xu L R, Su B, Fang Q. Biosens. Bioelectron., 2014, 53:148-153
52. [52]
  52 Witters D, Knez K, Ceyssens F, Puers R, Lammertyn J. Lab Chip, 2013, 13(11):2047-205452 Witters D, Knez K, Ceyssens F, Puers R, Lammertyn J. Lab Chip, 2013, 13(11):2047-2054
53. [53]
  53 Pessi J, Santos H A, Miroshnyk I, Yliruusi J, Weitz D A, Mirza S. Int. J. Pharm., 2014, 472(1-2):82-8753 Pessi J, Santos H A, Miroshnyk I, Yliruusi J, Weitz D A, Mirza S. Int. J. Pharm., 2014, 472(1-2):82-87
54. [54]
  54 Ganan-Calvo A M, Montanero J M, Martin-Banderas L, Flores-Mosquera M. Adv. Drug. Deliver. Rev., 2013, 65(11-12):1447-146954 Ganan-Calvo A M, Montanero J M, Martin-Banderas L, Flores-Mosquera M. Adv. Drug. Deliver. Rev., 2013, 65(11-12):1447-1469
55. [55]
  55 Kong F, Zhang X, Hai M T. Langmuir, 2014, 30(13):3905-391255 Kong F, Zhang X, Hai M T. Langmuir, 2014, 30(13):3905-3912
56. [56]
  56 Sarkar S, Cohen N, Sabhachandani P, Konry T. Lab Chip, 2015, 15(23):4441-445056 Sarkar S, Cohen N, Sabhachandani P, Konry T. Lab Chip, 2015, 15(23):4441-4450
57. [57]
  57 CHEN Jiu-Sheng, JIANG Jia-Huan. Chinese J. Anal. Chem., 2012, 40(8):1293-1300 陈九生, 蒋稼欢. 分析化学, 2012, 40(8):1293-130057 CHEN Jiu-Sheng, JIANG Jia-Huan. Chinese J. Anal. Chem., 2012, 40(8):1293-1300 陈九生, 蒋稼欢. 分析化学, 2012, 40(8):1293-1300
58. [58]
  58 SHEN Feng, LI Yi, LIU Zhao-Miao, CAO Ren-Tuo, WANG Gui-Ren. Chinese J. Anal. Chem., 2015, 43(12):1942-1954 申峰, 李易, 刘赵淼, 曹刃拓, 王贵人. 分析化学, 2015, 43(12):1942-195458 SHEN Feng, LI Yi, LIU Zhao-Miao, CAO Ren-Tuo, WANG Gui-Ren. Chinese J. Anal. Chem., 2015, 43(12):1942-1954 申峰, 李易, 刘赵淼, 曹刃拓, 王贵人. 分析化学, 2015, 43(12):1942-1954
59. [59]
  59 LIU Wen-Ming, LI Li, REN Li, WANG Jian-Chun, TU Qin, WANG Xue-Qin, WANG Jin-Yi. Chin. J. Anal. Chem., 2012, 40(1):24-31 刘文明, 李立, 任丽, 王建春, 涂琴, 王雪琴, 王进义. 分析化学, 2012, 40(1):24-3159 LIU Wen-Ming, LI Li, REN Li, WANG Jian-Chun, TU Qin, WANG Xue-Qin, WANG Jin-Yi. Chin. J. Anal. Chem., 2012, 40(1):24-31 刘文明, 李立, 任丽, 王建春, 涂琴, 王雪琴, 王进义. 分析化学, 2012, 40(1):24-31
60. [60]
  60 CAI Ya-Mei, HONG Zhan-Ying, ZHU Zhen-Yu, CHAI Yi-Feng. Chin. J. Pharm. Anal., 2013, 33(11):2013-2018 蔡亚梅, 洪战英, 朱臻宇, 柴逸峰. 药物分析杂志, 2013, 33(11):2013-201860 CAI Ya-Mei, HONG Zhan-Ying, ZHU Zhen-Yu, CHAI Yi-Feng. Chin. J. Pharm. Anal., 2013, 33(11):2013-2018 蔡亚梅, 洪战英, 朱臻宇, 柴逸峰. 药物分析杂志, 2013, 33(11):2013-2018

扫一扫看文章

计量

PDF下载量: 1
文章访问数: 1241
HTML全文浏览量: 71

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

液滴微流控技术在生物医学中的应用进展

通讯作者: 王进义

English

Application Progress of Droplet-based Microfluidics in Biomedicine

Corresponding author: 王进义

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

液滴微流控技术在生物医学中的应用进展

通讯作者: 王进义

English

Application Progress of Droplet-based Microfluidics in Biomedicine

Corresponding author: 王进义

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs