引用本文:
Yong Hai Liu, Da Li Li, Lu De Lu, Zhen Yuan Miao. Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol[J]. Chinese Chemical Letters,
2008, 19(7): 814-816.
doi:
10.1016/j.cclet.2008.05.009
Citation: Yong Hai Liu, Da Li Li, Lu De Lu, Zhen Yuan Miao. Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol[J]. Chinese Chemical Letters, 2008, 19(7): 814-816. doi: 10.1016/j.cclet.2008.05.009
Citation: Yong Hai Liu, Da Li Li, Lu De Lu, Zhen Yuan Miao. Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol[J]. Chinese Chemical Letters, 2008, 19(7): 814-816. doi: 10.1016/j.cclet.2008.05.009
Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
摘要:
A convenient approach for the preparation of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1 is developed.The target compound via four steps is synthesized from 4-bromo-2-(bromomethyl)-1-chlorobenzene and the isomers of undesired ortho-products were avoided during the preparation.
English
Convenient synthesis of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
Abstract:
A convenient approach for the preparation of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1 is developed.The target compound via four steps is synthesized from 4-bromo-2-(bromomethyl)-1-chlorobenzene and the isomers of undesired ortho-products were avoided during the preparation.
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Key words:
- Type 2 diabetes
- / Sodium glucose co-transporter 2
- / Inhibitor
- / Preparation
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