器官芯片及其应用

引用本文: 孙威, 陈雨晴, 罗国安, 张敏, 章弘扬, 王月荣, 胡坪. 器官芯片及其应用[J]. 分析化学, 2016, 44(4): 533-541. doi: 10.11895/j.issn.0253-3820.150857 shu

Citation: SUN Wei, CHEN Yu-Qing, LUO Guo-An, ZHANG Min, ZHANG Hong-Yang, WANG Yue-Rong, HU Ping. Organs-on-chips and Its Applications[J]. Chinese Journal of Analytical Chemistry, 2016, 44(4): 533-541. doi: 10.11895/j.issn.0253-3820.150857 shu

器官芯片及其应用

孙威 ^1, ,
陈雨晴 ^1, ,
罗国安 ^2,3, ,
张敏 ^3, ,
章弘扬 ^1, ,
王月荣 ^1, ,
胡坪 ^{1,
,}

1.
¹ 上海市功能性材料化学重点实验室, 华东理工大学化学与分子工程学院, 上海 200237;
2.
² 清华大学化学系, 北京 10084;
3.
³ 华东理工大学药学院上海市新药设计重点实验室, 上海 200237

通讯作者: 胡坪

基金项目:
本文系国家"重大新药创制"科技重大专项(No.2013ZX09507005)资助 (No.2013ZX09507005)

摘要: 微流控芯片是细胞体外培养的重要平台,基于该平台所发展的器官芯片技术更因其能够模拟人体器官的复杂结构及功能而受到重视。本文从不同器官的角度介绍了近年来器官芯片技术在构建人体生理学模型、药物研发及毒理学研究中的应用,并对器官芯片技术的发展前景进行了展望。

关键词:

English

Organs-on-chips and Its Applications

1.
¹ Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;
2.
² Department of Chemistry, Tsinghua University, Beijing 10084, China;
3.
³ Shanghai Key Laboratory of New Drug Design & Modern Engineering Center for TCM, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Corresponding author: 胡坪

Received Date: 26 October 2015
Fund Project:
本文系国家"重大新药创制"科技重大专项(No.2013ZX09507005)资助

Abstract: Microfluidic chips are significant platforms of cell culture in vitro. Microfluidic chip-based organs-on-chips technology has received attention because it can mimic the complex structures and functions of human organs. In this review, the recent advances of organs-on-chips technology in different organs are reported including the build of human physiological models, drug discovery and toxicology research. And the development of this technology is proposed.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

器官芯片及其应用

通讯作者: 胡坪

English

Organs-on-chips and Its Applications

Corresponding author: 胡坪

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

器官芯片及其应用

通讯作者: 胡坪

English

Organs-on-chips and Its Applications

Corresponding author: 胡坪

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs