引用本文:
Jin Pei Zhou, Yi Wei Ding, Hui Bin Zhang, Lian Xu, Yue Dai. Synthesis and anti-inflammatory activity of imidazo [1,2-a] pyrimidine derivatives[J]. Chinese Chemical Letters,
2008, 19(6): 669-672.
doi:
10.1016/j.cclet.2008.04.020
Citation: Jin Pei Zhou, Yi Wei Ding, Hui Bin Zhang, Lian Xu, Yue Dai. Synthesis and anti-inflammatory activity of imidazo [1,2-a] pyrimidine derivatives[J]. Chinese Chemical Letters, 2008, 19(6): 669-672. doi: 10.1016/j.cclet.2008.04.020
Citation: Jin Pei Zhou, Yi Wei Ding, Hui Bin Zhang, Lian Xu, Yue Dai. Synthesis and anti-inflammatory activity of imidazo [1,2-a] pyrimidine derivatives[J]. Chinese Chemical Letters, 2008, 19(6): 669-672. doi: 10.1016/j.cclet.2008.04.020
Synthesis and anti-inflammatory activity of imidazo [1,2-a] pyrimidine derivatives
摘要:
A series of imidazo [1,2-a] pyrimidine derivatives substituted adjacently with two aryls at positions 2 and 3 were designed and synthesized in order to improve their anti-inflammatory activities. Biological tests suggested that these compounds have antiinflammatory activities with COX-2 selectivity to some extent.
English
Synthesis and anti-inflammatory activity of imidazo [1,2-a] pyrimidine derivatives
Abstract:
A series of imidazo [1,2-a] pyrimidine derivatives substituted adjacently with two aryls at positions 2 and 3 were designed and synthesized in order to improve their anti-inflammatory activities. Biological tests suggested that these compounds have antiinflammatory activities with COX-2 selectivity to some extent.
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Key words:
- Imidazo [1,2-a] pyrimidine
- / Cyclooxygenase-2
- / Anti-inflammatory
- / Synthesis
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