引用本文:
黄忠京, 杨瑞云, 郭志勇, 佘志刚, 林永成. 培养南海红树林内源真菌Fusarium sp. ZZF60产新型蒽醌衍生物[J]. 应用化学,
2010, 27(4): 394-397.
doi:
10.3724/SP.J.1095.2010.90377
Citation: HUANG Zhong-Jinga, YANG Run-Yunb, GUO Zhi-Yongb, SHE Zhi-Gangb, LIN Yong-Cheng. New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea[J]. Chinese Journal of Applied Chemistry, 2010, 27(4): 394-397. doi: 10.3724/SP.J.1095.2010.90377
Citation: HUANG Zhong-Jinga, YANG Run-Yunb, GUO Zhi-Yongb, SHE Zhi-Gangb, LIN Yong-Cheng. New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea[J]. Chinese Journal of Applied Chemistry, 2010, 27(4): 394-397. doi: 10.3724/SP.J.1095.2010.90377
培养南海红树林内源真菌Fusarium sp. ZZF60产新型蒽醌衍生物
摘要:
通过人工发酵培养,从南海红树林内源真菌Fusarium sp.ZZF60的培养液中分离得到:1种新蒽醌衍生物,6,8-二甲氧基-1-甲基-2-(3-氧丁基)蒽醌(1),以及5种已知化合物:7-羟基-3-(4-甲氧基苯基)苯并-γ-吡喃酮(2),2,4-二羟基-6-[(1'E,3'E)-1',3'-戊二烯基]苯甲醛(3),(E)-4-羟基肉桂酸甲酯(4),4-(4-羟基苯基)-2-丁醇(5),4-羟基苯甲酸(6)。它们的结构通过MS、NMR等波谱分析推导确定。初步药理活性显示,化合物1抑制体外培养人喉癌细胞Hep2和人肝癌细胞HepG2的IC50分别为16和23μmol/L。
English
New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea
Abstract:
A new anthraquinone derivative,6,8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone(1),together with five known compounds,7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2),2,4-dihydroxy-6-[(1'E,3'E)-penta-1',3'-dienyl]-benzaldehyde(3),(E)-4hydroxycinnamic acid methyl ester(4),4-(4-hydroxyphenyl)-butan2-ol(5),and 4-hydroxybenzoic acid(6),were isolated from the marine mangrove endophytic fungus Fusarium sp.ZZF60 from the South China Sea.Their structures were elucidated by spectral data of IR,MS and NMR.In the preliminary bioassay,compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC50 values of 16 μmol/L and 23 μmol/L,respectively.
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Key words:
- mangrove endophytic fungus
- / ZZF60
- / metabolites
- / anthraquinone
- / antitumor activity
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