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循环肿瘤DNA检测研究新进展

陈欢 ,  韩鑫涛 ,  魏佳 ,  刘嘉男 ,  王国庆 ,  刘万建 ,  田永帅 ,  孟宪瑛 ,  王振新

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引用本文: 陈欢, 韩鑫涛, 魏佳, 刘嘉男, 王国庆, 刘万建, 田永帅, 孟宪瑛, 王振新. 循环肿瘤DNA检测研究新进展[J]. 分析化学, 2021, 49(6): 893-906. doi: 10.19756/j.issn.0253-3820.211106 shu
Citation:  CHEN Huan,  HAN Xin-Tao,  WEI Jia,  LIU Jia-Nan,  WANG Guo-Qing,  LIU Wan-Jian,  TIAN Yong-Shuai,  MENG Xian-Ying,  WANG Zhen-Xin. Recent Progress of Detection of Circulating Tumor DNA[J]. Chinese Journal of Analytical Chemistry, 2021, 49(6): 893-906. doi: 10.19756/j.issn.0253-3820.211106 shu

循环肿瘤DNA检测研究新进展

  • 1.

    青岛汉唐生物科技有限公司, 青岛 266000;

  • 2.

    中国科学院长春应用化学研究所电分析化学国家重点实验室, 长春 130022;

  • 3.

    吉林大学白求恩第一临床医院甲状腺外科, 长春 130021

    • 通讯作者: 田永帅,E-mail:tian_yongshuai@163.com; 孟宪瑛,E-mail:mengxiany@jlu.edu.cn; 王振新,E-mail:wangzx@ciac.ac.cn
  • 基金项目:

    吉林省自然科学基金（学科布局项目）（No.20200201357JC）和山东省泰山产业领军人才工程项目（No.2019TSCYCX-24）资助。

摘要: 循环肿瘤DNA （Circulating tumor DNA，ctDNA）是源自于肿瘤的一种无细胞DNA （Cell free DNA，cfDNA），可能携带与原发肿瘤相同的致癌突变和基因改变。因此，ctDNA有望作为癌症的无创监测生物标志物。研发ctDNA分析新方法可促进用于癌症诊断、预后评估、疗效监测和遗传/表观遗传异常研究的液体活检技术的发展。在过去的几十年中，基于聚合酶链反应（Polymerase chain reaction，PCR）、二代测序（Next-generation sequencing，NGS）等传统的DNA检测技术已被广泛应用于临床样本中ctDNA检测。近来，研究者针对传统DNA检测技术灵敏度较低的问题，研发了多种高性能ctDNA生物传感器用于分析癌症患者血液样本中的ctDNA，为其高灵敏检测提供了新的技术手段。本文综述了ctDNA的分析方法，尤其是近五年来ctDNA生物传感器研究的新进展，探讨了其进入实际临床应用需要解决的技术挑战，为研发癌症液体活检新方法提供了参考。

English


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  • 收稿日期:  2021-02-04
  • 修回日期:  2021-03-31
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