基于智能手机拍照判读的侧流免疫层析快速检测技术研究进展

引用本文: 李辉, 盈盈, 曹振, 刘广洋, 王静. 基于智能手机拍照判读的侧流免疫层析快速检测技术研究进展[J]. 分析化学, 2022, 50(1): 1-11. doi: 10.19756/j.issn.0253-3820.201488 shu

Citation: LI Hui, YING Ying, CAO Zhen, LIU Guang-Yang, WANG Jing. Research Progress on Rapid Detection Technology Based on Smartphone and Lateral Flow Immunoassay[J]. Chinese Journal of Analytical Chemistry, 2022, 50(1): 1-11. doi: 10.19756/j.issn.0253-3820.201488 shu

基于智能手机拍照判读的侧流免疫层析快速检测技术研究进展

李辉 ^1, ,
盈盈 ^1, ,
曹振 ^{1,
,} ,
刘广洋 ^2, ,
王静 ^{1,
,}

1.
中国农业科学院农业质量标准与检测技术研究所, 农业农村部农产品质量安全重点实验室, 北京 100081;
2.
中国农业科学院蔬菜花卉研究所, 农业农村部蔬菜质量安全控制重点实验室, 农业农村部蔬菜产品质量安全风险评估实验室, 北京 100081

通讯作者: 曹振,E-mail:caozhen01@caas.cn; 王静,E-mail:w_jing2001@126.com

基金项目:
中国农业科学院科技创新工程重大科研任务项目（No.CAAS-ZDRW202011）资助。

摘要: 侧流免疫层析试纸条是目前市场上主流的快检产品，具备内置高清摄像头的智能手机近年来已经在消费者中普及，通过手机拍照结合机器视觉图像识别技术，基于可见光比色分析或荧光分析技术，将试纸条显色的光学信号转化为数字信号，实现对试纸条显色结果的快速定性/定量判定，已经成为近年来快速检测的研究热点。本文评述了基于智能手机拍照判读的侧流免疫层析快检技术在医疗诊断、环境监测和食品安全领域的应用进展，总结了基于智能手机拍照实现试纸条快检产品定量检测的模式、技术路线，对其发展前景和实际应用中面临的挑战等进行了探讨。

关键词:

English

Research Progress on Rapid Detection Technology Based on Smartphone and Lateral Flow Immunoassay

LI Hui ^1, ,
YING Ying ^1, ,
CAO Zhen ^{1,
,} ,
LIU Guang-Yang ^2, ,
WANG Jing ^{1,
,}

1.
Key Laboratory of Agro-product Quality and Safety, Ministry of Agriculture and Rural Affairs, Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China;
2.
Key Laboratory of Vegetables Quality and Safety Control, Ministry of Agriculture and Rural Affairs, Ministry of Agriculture Vegetable Product Quality Safety Risk Assessment Laboratory, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Corresponding author: CAO Zhen, ; WANG Jing,

Received Date: 12 August 2021
Revised Date: 15 October 2021
Fund Project:
Supported by the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences (No.CAAS-ZDRW202011).

Abstract: Lateral flow immunochromatographic strip is one of the mainstream rapid detection products in the current market. Smartphones with built-in high-definition cameras have been popular among consumers in recent years. By taking a picture via mobile phones, then analyzing with machine vision image recognition technology, the optical signal of strip developed color could be converted into digital signal based on visible light colorimetric analysis or fluorescence analysis technology. This has become a research hotspot of rapid detection to realize qualitative or quantitative determination based on strip color development in recent years. In this paper, the applications of rapid detection technology based on smartphone and lateral flow immunoassay in medical diagnosis, environmental monitoring and food safety were reviewed. Moreover, the quantitative detection mode, implementation method and challenges of rapid test strip products based on smartphone photography were also discussed and summarized, which could provide reference for its realization of multi-target analysis, on-site rapid qualitative and quantitative detection.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

基于智能手机拍照判读的侧流免疫层析快速检测技术研究进展

通讯作者: 曹振,E-mail:caozhen01@caas.cn; 王静,E-mail:w_jing2001@126.com

English

Research Progress on Rapid Detection Technology Based on Smartphone and Lateral Flow Immunoassay

Corresponding author: CAO Zhen, ; WANG Jing,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于智能手机拍照判读的侧流免疫层析快速检测技术研究进展

通讯作者: 曹振,E-mail:caozhen01@caas.cn; 王静,E-mail:w_jing2001@126.com

English

Research Progress on Rapid Detection Technology Based on Smartphone and Lateral Flow Immunoassay

Corresponding author: CAO Zhen, ; WANG Jing,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs