引用本文:
Cheng Lu ZHANG, Ping Yan BIE, Xuan Jia PENG, Xin Fu PAN. Total Synthesis of (±)-Nimbonone and (±)-12-Ethyl-13-methoxy-8,11,13-podocarpatriene[J]. Chinese Chemical Letters,
2002, 13(10): 935-936.
Citation: Cheng Lu ZHANG, Ping Yan BIE, Xuan Jia PENG, Xin Fu PAN. Total Synthesis of (±)-Nimbonone and (±)-12-Ethyl-13-methoxy-8,11,13-podocarpatriene[J]. Chinese Chemical Letters, 2002, 13(10): 935-936.
Citation: Cheng Lu ZHANG, Ping Yan BIE, Xuan Jia PENG, Xin Fu PAN. Total Synthesis of (±)-Nimbonone and (±)-12-Ethyl-13-methoxy-8,11,13-podocarpatriene[J]. Chinese Chemical Letters, 2002, 13(10): 935-936.
Total Synthesis of (±)-Nimbonone and (±)-12-Ethyl-13-methoxy-8,11,13-podocarpatriene
摘要:
A facile total synthetic route to (±)-nimbonone and (±)-12-ethyl-13-methoxy-8,11,13-podocarpatriene was developed. The Wittig reaction of α-cyclocitral with (3-methoxybenzyl) triphenylphosphonium and intramolecular cyclization with BF3·Et2O in the synthetic progress were applied. In order to induce the ethyl substituent, Fiedel-Crafts acetylation and then decarbonylation had been employed.
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关键词:
- Total synthesis
- / (±)-nimbonone
- / diterpene
English
Total Synthesis of (±)-Nimbonone and (±)-12-Ethyl-13-methoxy-8,11,13-podocarpatriene
Abstract:
A facile total synthetic route to (±)-nimbonone and (±)-12-ethyl-13-methoxy-8,11,13-podocarpatriene was developed. The Wittig reaction of α-cyclocitral with (3-methoxybenzyl) triphenylphosphonium and intramolecular cyclization with BF3·Et2O in the synthetic progress were applied. In order to induce the ethyl substituent, Fiedel-Crafts acetylation and then decarbonylation had been employed.
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Key words:
- Total synthesis
- / (±)-nimbonone
- / diterpene
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