Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

Citation: Li-li Yang, Jin-ming Zhang, Jia-song He, Jun Zhang, Zhi-hua Gan. Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers[J]. Chinese Journal of Polymer Science, 2015, 33(12): 1640-1649. doi: 10.1007/s10118-015-1703-2 shu

Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

1.
1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190, China
2.
2. University of Chinese Academy of Sciences, Beijing 100049, China
3.
4.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190, China
5.
State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomaterials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
基金项目:
This work was financially supported by the National Natural Science Foundation of China(No.51425307).

摘要: A new series of cellulose-graft-poly(N-isopropylacrylamide)(cellulose-g-PNIPAM) copolymers were prepared by atom transfer radical polymerization(ATRP) of N-isopropylacrylamide monomers from a cellulose-based macro-initiator, which was homogeneously synthesized in an ionic liquid 1-allyl-3-methylimidazolium chloride(AmimCl). The composition of cellulose-g-PNIPAM copolymers could be adjusted by altering the feeding ratio and reaction time. The resultant copolymers with relatively high content of PNIPAM segments(molar substitution of PNIPAM18.3) were soluble in water at room temperature. Aqueous solutions of cellulose-g-PNIPAM copolymers exhibited clear temperature-sensitive behavior, and their sol-to-gel phase transition properties were investigated by dynamic light scattering(DLS) and UV measurements. Compared with pure PNIPAM, the cellulose-g-PNIPAM copolymers possessed higher lower critical solution temperatures(LCST) in a range from 36.9℃ to 40.8℃, which are close to normal human body temperature, and could be tuned by adjusting the content of PNIPAM segments in copolymers. Spherical structure of cellulose-g-PNIPAM copolymers formed at temperatures above LCST and its morphology was observed by TEM and SEM. These novel cellulose-g-PNIPAM copolymers may be attractive substrates for some biomedical applications, such as drug release and tissue engineering.

关键词:

English

Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

1.
1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190, China
2.
2. University of Chinese Academy of Sciences, Beijing 100049, China
3.
4.
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences(CAS), Beijing 100190, China
5.
State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomaterials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China
Received Date: 29 April 2015
Revised Date: 14 May 2015
Available Online: 05 December 2015
Fund Project:
This work was financially supported by the National Natural Science Foundation of China(No.51425307).

Abstract: A new series of cellulose-graft-poly(N-isopropylacrylamide)(cellulose-g-PNIPAM) copolymers were prepared by atom transfer radical polymerization(ATRP) of N-isopropylacrylamide monomers from a cellulose-based macro-initiator, which was homogeneously synthesized in an ionic liquid 1-allyl-3-methylimidazolium chloride(AmimCl). The composition of cellulose-g-PNIPAM copolymers could be adjusted by altering the feeding ratio and reaction time. The resultant copolymers with relatively high content of PNIPAM segments(molar substitution of PNIPAM18.3) were soluble in water at room temperature. Aqueous solutions of cellulose-g-PNIPAM copolymers exhibited clear temperature-sensitive behavior, and their sol-to-gel phase transition properties were investigated by dynamic light scattering(DLS) and UV measurements. Compared with pure PNIPAM, the cellulose-g-PNIPAM copolymers possessed higher lower critical solution temperatures(LCST) in a range from 36.9℃ to 40.8℃, which are close to normal human body temperature, and could be tuned by adjusting the content of PNIPAM segments in copolymers. Spherical structure of cellulose-g-PNIPAM copolymers formed at temperatures above LCST and its morphology was observed by TEM and SEM. These novel cellulose-g-PNIPAM copolymers may be attractive substrates for some biomedical applications, such as drug release and tissue engineering.

Key words:

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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

English

Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

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Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

English

Synthesis and Characterization of Temperature-sensitive Cellulose-graft-Poly(N-isopropylacrylamide) Copolymers

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

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