引用本文:
刘艳珠, 李永绣, 李霞, 张玲. 硝酸铁对水杨酸甲酯的硝化及位置选择性[J]. 应用化学,
2010, 27(4): 432-436.
doi:
10.3724/SP.J.1095.2010.90336
Citation: LIU Yan-Zhu, LI Yong-Xiu, LI Xia, ZHANG Ling. Nitration Reaction betweem Methyl Salicylate and Iron(Ⅲ) Nitrate and Its Regioselectivity[J]. Chinese Journal of Applied Chemistry, 2010, 27(4): 432-436. doi: 10.3724/SP.J.1095.2010.90336
Citation: LIU Yan-Zhu, LI Yong-Xiu, LI Xia, ZHANG Ling. Nitration Reaction betweem Methyl Salicylate and Iron(Ⅲ) Nitrate and Its Regioselectivity[J]. Chinese Journal of Applied Chemistry, 2010, 27(4): 432-436. doi: 10.3724/SP.J.1095.2010.90336
硝酸铁对水杨酸甲酯的硝化及位置选择性
English
Nitration Reaction betweem Methyl Salicylate and Iron(Ⅲ) Nitrate and Its Regioselectivity
Abstract:
The nitration of methyl salicylate by iron(Ⅲ) nitrate was studied to obtain 3nitrosalicylate and 5-nitrosalicylate.The effects of reaction time,molar ratio of iron(Ⅲ) nitrate to methyl salicylate,acidity and basicity on the yield and regioselectivity were reported.When the reaction time is 3 h and the molar ratio of iron(Ⅲ) nitrate to methyl salicylate is 2:3,the yield is the highest.Furthermore,a small amount nitric acid is beneficial to the nitration and the formation of 5-nitrosalicylate,whereas a small amount base is not benefiical to the nitration but to the formation of 3-nitrosalicylate under a strong base condition.The regioselectivity was explained by the quatum chemical computations.
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Key words:
- iron(Ⅲ)nitrate
- / nitration
- / methyl salicylate
- / quatum chemical computation
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