引用本文:
张晓佳, 崔建国, 李莹, 范建春. 3β-羟基雄甾-4-烯-6,17-二酮合成的一种新方法[J]. 应用化学,
2010, 27(5): 615-617.
doi:
10.3724/SP.J.1095.2010.90429
Citation: ZHANG Xiao-Ji, CUI Jian-Guo, LI Ying, FAN Jian-Chun. A Novel Method for Synthesis of 3β-Hydroxyandrost-4-en-6,17-dione[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 615-617. doi: 10.3724/SP.J.1095.2010.90429
Citation: ZHANG Xiao-Ji, CUI Jian-Guo, LI Ying, FAN Jian-Chun. A Novel Method for Synthesis of 3β-Hydroxyandrost-4-en-6,17-dione[J]. Chinese Journal of Applied Chemistry, 2010, 27(5): 615-617. doi: 10.3724/SP.J.1095.2010.90429
3β-羟基雄甾-4-烯-6,17-二酮合成的一种新方法
摘要:
以去氢表雄酮(1)为原料,经过氯铬酸吡啶(PCC)氧化得到雄甾-4-烯-3,6,17-三酮(2),然后在Co2+存在下用NaBH4还原,得到芳香酶的强效抑制剂3β-羟基雄甾-4-烯-6,17-二酮(3)。与文献合成方法相比,反应步骤缩短,反应产率提高。化合物3的结构经NMR和IR测试技术进行了表征,与文献结果一致。
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关键词:
- 去氢表雄酮
- / 3β-羟基雄甾烯二酮
- / 合成
English
A Novel Method for Synthesis of 3β-Hydroxyandrost-4-en-6,17-dione
Abstract:
Dehydroepiandrosterone(1) was oxidized with pyridinium chlorochromate(PCC) to obtain androst-4-en-3,6,17-trione(2),which was then submitted to reduction with NaBH4 in the presence of Co2+ to obtain 3β-hydroxyandrost-4-en-6,17-dione(3),a non-androgenic aromatase inhibitor.Compared with literature's methods,this method shortens the reaction steps and improves the reaction yield.The structure of compound 3 was characterized by NMR and IR.
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Key words:
- dehydroepiandrosterone
- / 3β-hydroxyandrost-en-dione
- / synthesis
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