引用本文:
史兰香, 张宝华. O-去甲基文拉法辛合成的新方法[J]. 应用化学,
2013, 30(5): 608-610.
doi:
10.3724/SP.J.1095.2013.20351
Citation: SHI Lanxiang, ZHANG Baohu. New Method for Synthesizing O-Desmethylvenlafaxine[J]. Chinese Journal of Applied Chemistry, 2013, 30(5): 608-610. doi: 10.3724/SP.J.1095.2013.20351
Citation: SHI Lanxiang, ZHANG Baohu. New Method for Synthesizing O-Desmethylvenlafaxine[J]. Chinese Journal of Applied Chemistry, 2013, 30(5): 608-610. doi: 10.3724/SP.J.1095.2013.20351
O-去甲基文拉法辛合成的新方法
English
New Method for Synthesizing O-Desmethylvenlafaxine
Abstract:
The O-desmethylvenlafaxines were prepared from venlafaxine reacted with new demethylation reagents cysteine sodium and sodium penicillamine,respectively.The corresponding yields are 86% and 82%,respectively.Since the synthesis could be fulfilled in a one-pot approach by mixing cysteine sodium salt,sodium penicillamine preparation and venlafaxine demethylation together,the reaction was fairly simplified.The optimal reaction conditions are:N-methyl pyrrolidone as the solvent,reaction temperature of 175℃ and the pH value of 9.5 for product to crystallize.
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Key words:
- O-desmethylvenlafaxine
- / venlafaxine
- / demethylation
- / cysteine sodium
- / sodium penicillamine
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