Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of <i>N-</i>(3,5-Dibromosalicylidene)valine

Citation: TIAN Lai-Jin, YAO Yan-Ze, LIU Qing-Tao, ZHENG Xiao-Feng. Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine[J]. Chinese Journal of Structural Chemistry, 2016, 35(6): 849-856. doi: 10.14102/j.cnki.0254-5861.2011-1058 shu

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

1.
Department of Chemistry, Qufu Normal University, Qufu 273165, China

通讯作者: TIAN Lai-Jin,

基金项目:

ong Provincial Natural Science Foundation (ZR2013BM007) (ZR2013BM007)

ong Province (BS2014CL015) (BS2014CL015)

the National Natural Science Foundation of China (21302110) (21302110)

摘要: Three cyclohexyltin complexes of N-(3,5-dibromosalicylidene)valine (H₂L), Cy₃Sn(HL) (1), Cy₂SnL (2), and Cy₂SnL·Cy₃SnCl (3) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and ¹H and^{13C NMR spectra.}The crystal structures of 2 and 3 have been determined. Complex 2 belongs to the monoclinic system, space group P2₁/n with a = 21.250(8), b = 10.837(4), c = 23.050(8) Å, b = 93.193(9)°, V = 5300(3) Å³, Z = 8, D_c= 1.659 g/cm³, m ＝ 4.004 mm^-1, F(000) = 2624, R = 0.0471 and wR = 0.1015. Complex 3 belongs to the monoclinic system, space group P2₁ with a = 10.3452(10), b = 18.7665(18), c = 12.1483(12) Å, b = 103.374(2)°, V = 2294.5(4) Å³, Z = 2, D_c= 1.542 g/cm³, m = 2.923 mm^-1, F(000) = 1072, R = 0.0428 and wR = 0.0936. Complex 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand, and 3 reveals that the two tin atoms are joined via the carbonyl atom of the ligand to form a mixed organotin binuclear complex. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli.

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English

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

1.
Department of Chemistry, Qufu Normal University, Qufu 273165, China

Corresponding author: TIAN Lai-Jin,

Received Date: 20 November 2015
Fund Project:

Abstract: Three cyclohexyltin complexes of N-(3,5-dibromosalicylidene)valine (H₂L), Cy₃Sn(HL) (1), Cy₂SnL (2), and Cy₂SnL·Cy₃SnCl (3) (Cy = cyclohexyl), have been synthesized and characterized by elemental analysis, IR, and ¹H and^{13C NMR spectra.}The crystal structures of 2 and 3 have been determined. Complex 2 belongs to the monoclinic system, space group P2₁/n with a = 21.250(8), b = 10.837(4), c = 23.050(8) Å, b = 93.193(9)°, V = 5300(3) Å³, Z = 8, D_c= 1.659 g/cm³, m ＝ 4.004 mm^-1, F(000) = 2624, R = 0.0471 and wR = 0.1015. Complex 3 belongs to the monoclinic system, space group P2₁ with a = 10.3452(10), b = 18.7665(18), c = 12.1483(12) Å, b = 103.374(2)°, V = 2294.5(4) Å³, Z = 2, D_c= 1.542 g/cm³, m = 2.923 mm^-1, F(000) = 1072, R = 0.0428 and wR = 0.0936. Complex 2 has a distorted trigonal bipyramidal geometry with the axial locations occupied by one carboxylate oxygen and a phenolic oxygen of the ligand, and 3 reveals that the two tin atoms are joined via the carbonyl atom of the ligand to form a mixed organotin binuclear complex. Bioassay results show that 1 and 2 have good in vitro antibacterial activity against Escherichia coli.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

通讯作者: TIAN Lai-Jin,

English

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

Corresponding author: TIAN Lai-Jin,

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

通讯作者: TIAN Lai-Jin,

English

Synthesis, Characterization and Antibacterial Activity of Cyclohexyltin Complexes of N-(3,5-Dibromosalicylidene)valine

Corresponding author: TIAN Lai-Jin,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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