引用本文:
刘建超, 贺红武. 噻吩并[2,3-b]吡啶类化合物的合成及生物活性[J]. 应用化学,
2010, 27(10): 1161-1164.
doi:
10.3724/SP.J.1095.2010.90876
Citation: LIU Jian-Chao, HE Hong-Wu. Synthesis and Biological Activities of Thieno [2,3-b] pyridine Derivatives[J]. Chinese Journal of Applied Chemistry, 2010, 27(10): 1161-1164. doi: 10.3724/SP.J.1095.2010.90876
Citation: LIU Jian-Chao, HE Hong-Wu. Synthesis and Biological Activities of Thieno [2,3-b] pyridine Derivatives[J]. Chinese Journal of Applied Chemistry, 2010, 27(10): 1161-1164. doi: 10.3724/SP.J.1095.2010.90876
噻吩并[2,3-b]吡啶类化合物的合成及生物活性
摘要:
用邻氨基噻吩腈与不同结构的二羰基化合物反应,合成了新的多取代噻吩并吡啶类衍生物4-氨基-5-取代羰基噻吩并[2,3-b]吡啶-6-酮。用元素分析、红外光谱、核磁共振氢谱和质谱等测试技术对所合成化合物的结构进行了表征。初步生物活性测试表明,该类化合物有较好的杀菌活性和一定的除草活性。
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关键词:
- 噻吩并[2,3-b]吡啶
- / 二羰基化合物
- / 杀菌活性
- / 除草活性
English
Synthesis and Biological Activities of Thieno [2,3-b] pyridine Derivatives
Abstract:
A facile synthetic method for thienopyridine derivatives was developed via the reaction of 2-aminothiophenes with acetoacetic ester and tin tetrachloride under heating.Four thienopyridine derivatives were obtained.The structures of the target compounds were determined by means of IR,1H NMR,MS and elemental analysis.Preliminary biological activities of the four thienopyridine derivatives showed that most of them display high fungicidal activities and a certain extent of herbicidal activities as well.
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Key words:
- thieno[2,3-b]pyridine
- / acetoacetic ester
- / fungicidal activities
- / herbicidal activities
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