引用本文:
吴洁, 张海江, 杨国军, 吴孝超. 二氧化碳沉淀法去除苯扎贝特中主要杂质[J]. 应用化学,
2015, 32(9): 1088-1092.
doi:
10.11944/j.issn.1000-0518.2015.09.150004
Citation: WU Jie, ZHANG Haijiang, YANG Guojun, WU Xiaochao. Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide[J]. Chinese Journal of Applied Chemistry, 2015, 32(9): 1088-1092. doi: 10.11944/j.issn.1000-0518.2015.09.150004
Citation: WU Jie, ZHANG Haijiang, YANG Guojun, WU Xiaochao. Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide[J]. Chinese Journal of Applied Chemistry, 2015, 32(9): 1088-1092. doi: 10.11944/j.issn.1000-0518.2015.09.150004
二氧化碳沉淀法去除苯扎贝特中主要杂质
English
Removal of the Main Impurity from Benzafibrate by a Precipitation Method with Carbon Dioxide
Abstract:
According to the acidicity difference between the main impurity and benzafibrate,carbon dioxide was introduced into the alkaline product solution to remove the impurity from benzafibrate in the post-treatment process.The yield and content of the treated products were determined to compare the separation effect with different methods of precipitation and recrystallization.Compared with recrystallization,the yield of the product treated with CO2 was increased from 62.5% to 70.9%.The method not only reduced the relatively large solvent consumption and product loss caused by the repeated recrystallization,but also effectively improved the removal rate of impurities and decreased the separation cost.
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Key words:
- benzafibrate
- / carbon dioxide
- / precipitation
- / impurity
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