引用本文:
许招会, 刘德勇, 涂缘鸿. 无溶剂硼酸高效合成螺杂双环衍生物[J]. 应用化学,
2015, 32(9): 999-1004.
doi:
10.11944/j.issn.1000-0518.2015.09.150038
Citation: XU Zhaohui, LIU Deyong, TU Yuanhong. Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst[J]. Chinese Journal of Applied Chemistry, 2015, 32(9): 999-1004. doi: 10.11944/j.issn.1000-0518.2015.09.150038
Citation: XU Zhaohui, LIU Deyong, TU Yuanhong. Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst[J]. Chinese Journal of Applied Chemistry, 2015, 32(9): 999-1004. doi: 10.11944/j.issn.1000-0518.2015.09.150038
无溶剂硼酸高效合成螺杂双环衍生物
English
Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst
Abstract:
Eight spiro heterobicyclic compounds were synthesized by the three component condensation reaction of aromatic aldehydes with urea and 2,2-dimethyl-1,3-dioxane-4,6-dione using boric acid as catalyst under solvent-free conditions.The results indicate that the yields range from 84% to 94% at 80℃ for 2.0~4.0 h using 10% molar fraction of boric acid (relative to the substrate of 2,2-dimethyl-1,3-dioxane-4,6-dione).Furthermore,a mechanism for the reaction catalyzed by boric acid was proposed.The main advantages of the present procedure are mild conditions,short reaction time and high yields.
-
-
扫一扫看文章
计量
- PDF下载量: 0
- 文章访问数: 453
- HTML全文浏览量: 40
下载:
