引用本文:
韩军兴, 刘彦钦, 韩士田. 间氯苯基锰卟啉-5-氟尿嘧啶配合物的合成及其对癌细胞的抑制活性[J]. 应用化学,
2012, 29(6): 718-720.
doi:
10.3724/SP.J.1095.2012.00354
Citation: HAN Junxing, LIU Yanqin, HAN Shitian. Synthesis of m-Chlorophenyl Mn-Porphyrin-5-Fluorouracil Complexes and Their Inhibition Activity to Cancer Cells[J]. Chinese Journal of Applied Chemistry, 2012, 29(6): 718-720. doi: 10.3724/SP.J.1095.2012.00354
Citation: HAN Junxing, LIU Yanqin, HAN Shitian. Synthesis of m-Chlorophenyl Mn-Porphyrin-5-Fluorouracil Complexes and Their Inhibition Activity to Cancer Cells[J]. Chinese Journal of Applied Chemistry, 2012, 29(6): 718-720. doi: 10.3724/SP.J.1095.2012.00354
间氯苯基锰卟啉-5-氟尿嘧啶配合物的合成及其对癌细胞的抑制活性
摘要:
合成了4种5-氟尿嘧啶-卟啉衍生物:5-[3-(2-(5-氟尿嘧啶-1-基)乙氧基)苯基]-10,15,20-三(3-氯苯基)卟啉(1a)、5-[3-(2-(5-氟尿嘧啶-1-基)乙氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2a)、5-[3-(3-(5-氟尿嘧啶-1-基)丙氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2b)和5-[3-(4-(5-氟尿嘧啶-1-基)丁氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2c),通过UV-Vis、IR、MS及元素分析表征了它们的结构。用噻唑蓝法(MTT法)测定了化合物2a、2b和2c对人胃癌细胞株BGC-823的抑制活性。化合物2b的半数抑制浓度IC50为1.34 μmol/L,表明有一定的细胞毒作用。
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关键词:
- 锰卟啉
- / 氟尿嘧啶
- / 合成
- / 人胃癌细胞株BGC-823
English
Synthesis of m-Chlorophenyl Mn-Porphyrin-5-Fluorouracil Complexes and Their Inhibition Activity to Cancer Cells
Abstract:
Four porphyrin-5-fluorouracil conjugates,i.e.5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)porphyrin(1a),5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2a),5-[3-(3-(5-fluorouracil-1-yl)-propoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2b) and 5-[3-(4-(5-fluorouracil-1-yl)-butoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2c),were successfully synthesized and characterized by UV-Vis,IR,MS and elemental analysis.Inhibition activity of the synthesized compounds(2a,2b and 2c) to human gastric cancer cell line BGC-823 was tested using the methyl thiazolyl tetrazolium(MTT) method.The IC50 value of 2b was 1.34 μmol/L,indicating that compound 2b had certain cytotoxic effect.
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Key words:
- manganoporphyrin
- / fluorouracil
- / synthesis
- / human gastric cancer cell line BGC-823
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