CdTe/CdS量子点与丝裂霉素的相互作用及其应用

引用本文: 李萍萍, 殷鹏飞, 龚会平, 刘正清, 王晓丹, 何佑秋. CdTe/CdS量子点与丝裂霉素的相互作用及其应用[J]. 应用化学, 2012, 29(6): 705-710. doi: 10.3724/SP.J.1095.2012.00326 shu

Citation: LI Pingping, YIN Pengfei, GONG Huiping, LIU Zhengqing, WANG Xiaodan, HE Youqiu. A Study on the Interactions Between CdTe/CdS Quantum Dots with Mitomycin C and Its Analytical Application[J]. Chinese Journal of Applied Chemistry, 2012, 29(6): 705-710. doi: 10.3724/SP.J.1095.2012.00326 shu

CdTe/CdS量子点与丝裂霉素的相互作用及其应用

1.
西南大学化学化工学院重庆 400715

通讯作者: 何佑秋,教授;Tel:023-68367475;Fax:023-68254000;E-mail:heyq@swu.edu.cn;研究方向:分子光谱分析

基金项目:
西南大学发光与实时分析重庆市重点实验室资助项目(CSTC,2006CA8006) (CSTC,2006CA8006)

摘要: 在水相中合成了硫普罗宁(Tiopronin,TP)修饰的CdTe/CdS量子点(TP-CdTe/CdS QDs)。利用紫外-可见吸收光谱、荧光光谱研究了TP-CdTe/CdS QDs与丝裂霉素(mitomycin C,MMC)的相互作用机理。在pH=7.6的tris-HCl缓冲溶液介质中,TP-CdTe/CdS QDs与MMC相互作用,使TP-CdTe/CdS QDs的荧光发生猝灭,并且QDs的荧光强度与MMC的浓度有良好的线性关系(r=0.999 1),线性范围4.7×10^-9~1.2×10^-8g/mL,检出限(3σ)为1.4×10^-8g/mL。此方法快速简便,用于尿样中丝裂霉素的测定,实验结果令人满意。

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A Study on the Interactions Between CdTe/CdS Quantum Dots with Mitomycin C and Its Analytical Application

1.
School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

Corresponding author: 何佑秋,教授;Tel:023-68367475;Fax:023-68254000;E-mail:heyq@swu.edu.cn;研究方向:分子光谱分析

Received Date: 22 July 2011
Fund Project:
西南大学发光与实时分析重庆市重点实验室资助项目(CSTC,2006CA8006)

Abstract: Tiopronin(TP) capped with CdTe/CdS quantum dots(TP-CdTe/CdS QDs) was synthesized in aqueous solution.The paper utilized ultraviolet-visible(UV-Vis) absorption spectra and fluorescence spectrometry to study the interactions between TP-CdTe/CdS QDs and mitomycin C(MMC).With the optimum reaction conditions which was found to be at pH=7.6 with tris-HCl buffer solution,the quenched fluorescence intensity of TP-CdTe/CdS QDs was linearly proportional with the concentration of MMC,correlation coefficient r=0.9991,and the detection limits were in the range of 4.7×10^-9~1.2×10^-8 g/mL,and the detection limit(3σ) for MMC was 1.4×10^-8 g/mL.The quantitative determination of MMC is quick,simple and convenient.This method has been applied to the determination of MMC in urine samples with satisfactory results.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

CdTe/CdS量子点与丝裂霉素的相互作用及其应用

通讯作者: 何佑秋,教授;Tel:023-68367475;Fax:023-68254000;E-mail:heyq@swu.edu.cn;研究方向:分子光谱分析

English

A Study on the Interactions Between CdTe/CdS Quantum Dots with Mitomycin C and Its Analytical Application

Corresponding author: 何佑秋,教授;Tel:023-68367475;Fax:023-68254000;E-mail:heyq@swu.edu.cn;研究方向:分子光谱分析

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CdTe/CdS量子点与丝裂霉素的相互作用及其应用

通讯作者: 何佑秋,教授;Tel:023-68367475;Fax:023-68254000;E-mail:heyq@swu.edu.cn;研究方向:分子光谱分析

English

A Study on the Interactions Between CdTe/CdS Quantum Dots with Mitomycin C and Its Analytical Application

Corresponding author: 何佑秋,教授;Tel:023-68367475;Fax:023-68254000;E-mail:heyq@swu.edu.cn;研究方向:分子光谱分析

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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