引用本文:
丁道远, 胡皆汉, 杨志勇. 顺铂、碳铂与鸟苷、L-蛋氨酸反应动力学比较研究[J]. 应用化学,
1992, 9(3): 114-117.
Citation: Ding Daoyuan, Hu Jiehan, Yang Zhiyong. REACTION KINETICS OF CDDP,CBDCA WITH GUANOSINE AND L-Met[J]. Chinese Journal of Applied Chemistry, 1992, 9(3): 114-117.
Citation: Ding Daoyuan, Hu Jiehan, Yang Zhiyong. REACTION KINETICS OF CDDP,CBDCA WITH GUANOSINE AND L-Met[J]. Chinese Journal of Applied Chemistry, 1992, 9(3): 114-117.
顺铂、碳铂与鸟苷、L-蛋氨酸反应动力学比较研究
English
REACTION KINETICS OF CDDP,CBDCA WITH GUANOSINE AND L-Met
Abstract:
The reaction kinetics of CDDP (cisplatin), CEDCA (carboplatin) with guanosine and L-Met are compared by means of HPLC.The results show that the reaction rate of CDDP with Guo is greater than that with CBDCA. However, CBDCA gave more 1:2 products with Guo than 1:1 products and its second hydrolysis rate constant k2 is much greater than its first one k1.For reactions of CDDP and CBDCA with L-Met the second rate constants are measured as 36.1×10-3 and 5.0×10-3M-1S-1, respectively. This may be one of the reasons that CBDCA shows less nephrotoxicity than CBDP.
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Key words:
- cisplatin(CDDP)
- / carboplatin(CBDCA)
- / guanosine
- / L-Met
- / HPLC
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