引用本文:
赵地顺, 史兰香, 徐志栋, 陈焕章, 荣杰. 青霉素亚砜催化扩环制备头孢G酸[J]. 应用化学,
2000, 17(3): 346-348.
Citation: ZHAO Di-Shun, SHI Lan-Xiang, XU Zhi-Dong, CHEN Huan-Zhang, RONG Jie. Preparation of 7-(Phenylacetamido)deacetoxycephalosporin Acid via Catalytic Ring-Expansion of Penicillin G Sulfoxide[J]. Chinese Journal of Applied Chemistry, 2000, 17(3): 346-348.
Citation: ZHAO Di-Shun, SHI Lan-Xiang, XU Zhi-Dong, CHEN Huan-Zhang, RONG Jie. Preparation of 7-(Phenylacetamido)deacetoxycephalosporin Acid via Catalytic Ring-Expansion of Penicillin G Sulfoxide[J]. Chinese Journal of Applied Chemistry, 2000, 17(3): 346-348.
青霉素亚砜催化扩环制备头孢G酸
English
Preparation of 7-(Phenylacetamido)deacetoxycephalosporin Acid via Catalytic Ring-Expansion of Penicillin G Sulfoxide
Abstract:
The 7-(phenylacetamido)deacetoxycephalosporin acid was prepared by ring expansion of penicillin G sulfoxide via its trimethylsiliated intermediate(protective silylation with N,N'-dimethylsilylurea) using HBr-4-methylpyridine as catalyst. The effects of catal-yst amount, reaction temperature and time were examined. Under optimum reaction condi tions product in 94% yield was obtained. The product has been characterized by IR and MS.
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