引用本文:
赵辉, 薛翠花, 牟其明, 李玲, 陈淑华. 脱氧胆酸类分子钳对氨基酸甲酯的手性识别[J]. 应用化学,
2001, 18(8): 614-617.
Citation: ZHAO Hui, XUE Cui-Hua, MU Qi Ming, LI Ling, CHEN Shu-Hua. Enantioselective Recognition of Amino Acid Methyl Ester by Chiral Molecular Tweezers Derived from Deoxycholic Acid[J]. Chinese Journal of Applied Chemistry, 2001, 18(8): 614-617.
Citation: ZHAO Hui, XUE Cui-Hua, MU Qi Ming, LI Ling, CHEN Shu-Hua. Enantioselective Recognition of Amino Acid Methyl Ester by Chiral Molecular Tweezers Derived from Deoxycholic Acid[J]. Chinese Journal of Applied Chemistry, 2001, 18(8): 614-617.
脱氧胆酸类分子钳对氨基酸甲酯的手性识别
English
Enantioselective Recognition of Amino Acid Methyl Ester by Chiral Molecular Tweezers Derived from Deoxycholic Acid
Abstract:
The molecular recognition properties of four chiral molecular tweezers derived from deoxycholic acid for amino acid methyl esters have been investigated by UV Vis spectroscopic titration. The association constants (Ka) and Gibbs free energy changes (-ΔG0) have been calculated. The results show that all the molecular tweezers 1~4 can form 1:1 inclusion complexes with methyl esters of D/L-phenylalanine and leucine. The recognition ability of these receptors comes mainly from hydrogen bonding and van der Waals interaction. The size/shape-fitting and geometrical complement between receptor and substrate play an important role in the inclusion complexation of amino acid methyl esters with molecular tweezers 1~4.
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Key words:
- chiral recognition
- / molecular tweezer
- / deoxycholic acid
- / amino acid
- / UV spectroscopy
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