引用本文:
金健民, 刘秀芳, 徐汉生. 甘草次酸衍生物的合成及其抗癌活性[J]. 应用化学,
2001, 18(11): 869-872.
Citation: JIN Jian-Ming, LIU Xiu-Fang, XU Han-Sheng. Synthesis and Antitumor Activity of Glycyrrhetic Acid Derivatives[J]. Chinese Journal of Applied Chemistry, 2001, 18(11): 869-872.
Citation: JIN Jian-Ming, LIU Xiu-Fang, XU Han-Sheng. Synthesis and Antitumor Activity of Glycyrrhetic Acid Derivatives[J]. Chinese Journal of Applied Chemistry, 2001, 18(11): 869-872.
甘草次酸衍生物的合成及其抗癌活性
English
Synthesis and Antitumor Activity of Glycyrrhetic Acid Derivatives
Abstract:
Six new glycyrrhetic acid derivatives were synthesized from the reaction of di(2-chloroethyl)aminophosohonyl dichloride(4) with methyl glycyrrhetinate(1), methyl-11-deoxy glycyrrhetinate(2), and 3-U-30-dioxy-12-ene oleanane(3), respectively. Their structures were confirmed by MS, 1H NMR and elemental analysis. The preliminary antitumor activity tests against EAC cells both in vitro and in rovo showed that the new compounds especially Ⅰa and Ⅰb exhibited a good antifumor activity in comparison with the nitrogen mustard.
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Key words:
- glycyrrhetinic acid
- / derivative
- / synthesis
- / antitumor activity
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