引用本文:
冯乙巳, 杨庆华, 黄庆云, 姚日生. 左旋丙叉甘油醇合成方法的改进[J]. 应用化学,
2005, 22(4): 460-461.
Citation: FENG Yi-Si, YANG Qing-Hua, HUANG Qing-Yun, YAO Ri-Sheng. Improvement on the Synthesis of Fork Glycerinol[J]. Chinese Journal of Applied Chemistry, 2005, 22(4): 460-461.
Citation: FENG Yi-Si, YANG Qing-Hua, HUANG Qing-Yun, YAO Ri-Sheng. Improvement on the Synthesis of Fork Glycerinol[J]. Chinese Journal of Applied Chemistry, 2005, 22(4): 460-461.
左旋丙叉甘油醇合成方法的改进
English
Improvement on the Synthesis of Fork Glycerinol
Abstract:
The optical active fork glycerinol (2,2-dimethyl-1,3-dioxolane-4-methanol)(1) was synthesized with L-serine (2) as the starting material.L-glyceric acid (3) was synthesized via the nitrosation of (2).With TsOH as the catalyst and 4A molecular sieve as the dehydration agent,LM-2,3-O-isopropylidene-glycerate (5) was directly prepared from (3),2,2'-dimethoxypropane and methanol without isolating the intermediate.Instead of LiAlH4,NaBH4 was used to reduce (5) to the final compound (1).The total yield of was 47%.
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Key words:
- L-serine
- / synthesis
- / fork glycerinol
- / dimethoxypropane
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