引用本文:
白莉, 高作宁. N-乙酰-L-半胱氨酸在10-甲基吩噻嗪修饰碳糊电极上的电催化氧化及电分析[J]. 应用化学,
2008, 25(6): 702-705.
Citation: BAI Li, GAO Zuo-Ning. Electrocatalytic Oxidation of N-Acetyl-L-Cysteine at 10-Methylphenothiazine Modified Carbon Paste Electrode and Its Practical Analytical Application[J]. Chinese Journal of Applied Chemistry, 2008, 25(6): 702-705.
Citation: BAI Li, GAO Zuo-Ning. Electrocatalytic Oxidation of N-Acetyl-L-Cysteine at 10-Methylphenothiazine Modified Carbon Paste Electrode and Its Practical Analytical Application[J]. Chinese Journal of Applied Chemistry, 2008, 25(6): 702-705.
N-乙酰-L-半胱氨酸在10-甲基吩噻嗪修饰碳糊电极上的电催化氧化及电分析
摘要:
研究了N-乙酰-L-半胱氨酸(N-Acetyl-L-Cysteine,NAC)在10-甲基吩噻嗪(10-Methylphenothiazine,MPT)修饰碳糊电极(MPT/CPE)上的电催化氧化行为。NAC在裸碳糊电极(Carbon paste electrode,CPE)上的直接电化学氧化过程十分迟缓,但在MPT/CPE上于0.697 V处出现1不可逆氧化峰,氧化电流大幅度增大。表明MPT/CPE对NAC电化学氧化有显著的催化作用。计时电流实验结果表明,电催化氧化反应速率常数k=(1.59±0.03)×103(mol·L-1)-1·s-1。用线性扫描伏安法(Linear Sweep Voltammetry,LSV)测得,催化氧化峰电流与NAC在1.0×10-6~1.3×10-3 mol/L浓度范围内呈良好的线性关系,线性回归方程Ipa(μA)=4.205 c(mmol/L)+4.333,R=0.9993,检测限为8.0×10-7 mol/L。用本方法对商品药富露施颗粒剂中NAC含量进行了测定,结果令人满意。
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关键词:
- N-乙酰-L-半胱氨酸
- / 甲基吩噻嗪
- / 碳糊修饰电极
- / 电催化氧化
- / 线性扫描伏安法
English
Electrocatalytic Oxidation of N-Acetyl-L-Cysteine at 10-Methylphenothiazine Modified Carbon Paste Electrode and Its Practical Analytical Application
Abstract:
The electrocatalytic oxidation of N-Acetyl-L-Cysteine (NAC) at a 10-methylphenothiazine (MPT) modified carbon paste electrode (MPT/CPE) was investigated by cyclic voltammetry (CV).Although NAC itself showed a very poor electrochemical response at a carbon paste electrode (CPE),the response could be greatly enhanced at MPT/CPE,which enables a sensitive electrochemical determination of substrate NAC.The reaction rate constant for the catalytic oxidation was evaluated to be (1.59±0.03)×103(mol·L-1)-1·s-1 by chronoamperometry (CA).The catalytic oxidation peak current of NAC vs its concentration had a good linear relationship in concentration range of 1.0×10-6~1.3×10-3 mol/L with a correlation coefficient of 0.999 3,and a detection limit of 8.0×10-7 mol/L by linear sweep voltammetry (LSV).This method can be applied to the determination of real samples.
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