引用本文:
张成路, 牛明铭, 许永廷, 陈颂, 申洪江, 广东, 刘林. 香草酰胺化合物的合成[J]. 应用化学,
2008, 25(6): 677-680.
Citation: ZHANG Cheng-Lu, NIU Ming-Ming, XU Yong-Ting, CHEN Song, SHEN Hong-Jiang, GUANG Dong, LIU Lin. Synthesis of Vanillyl Amide[J]. Chinese Journal of Applied Chemistry, 2008, 25(6): 677-680.
Citation: ZHANG Cheng-Lu, NIU Ming-Ming, XU Yong-Ting, CHEN Song, SHEN Hong-Jiang, GUANG Dong, LIU Lin. Synthesis of Vanillyl Amide[J]. Chinese Journal of Applied Chemistry, 2008, 25(6): 677-680.
香草酰胺化合物的合成
English
Synthesis of Vanillyl Amide
Abstract:
An efficient and high-yield synthesis of 3-methoxy-4-formylphenonyl p-methylbensulphonate (5) was accomplished with vanillin as the starting material in three steps.It involved the converstion of vanillin into hydrazine (4) and the metalic reduction of hydrazine 4 into the intermediate vanillic amine.The phosphonium 6 was synthesized in solid phase by the reaction of 6-bromohexyoic acid with triphenylphosphine,and then the Wittig condensation of phosphonium 6 with iso-butanol afforded 8-methoxynon-cis-6-enoic acid (7).Finally,compound 7 was connected with the amine 5,and then was hydrolyzed to the target compound under ultrasonic condition.IR,NMR and HRMS were used to confirm the structure of the title compound.
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Key words:
- vanillic amine
- / acylation
- / capsaicin
- / synthesis
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