引用本文:
秦宗会, 刘艳, 牛卫芬, 赵小辉. 某些酸性三苯甲烷染料与盐酸吡格列酮相互作用的分子光谱特点及其分析应用[J]. 应用化学,
2008, 25(9): 1017-1021.
Citation: QIN Zong-Hui, LIU Yan, NIU Wei-Fen, ZHAO Xiao-Hui. Molecular Spectral Characters of Interaction of Pioglitazone Hydrolchloride with Some Acidic Triphenylmethane Dyes and Their Analytical Applications[J]. Chinese Journal of Applied Chemistry, 2008, 25(9): 1017-1021.
Citation: QIN Zong-Hui, LIU Yan, NIU Wei-Fen, ZHAO Xiao-Hui. Molecular Spectral Characters of Interaction of Pioglitazone Hydrolchloride with Some Acidic Triphenylmethane Dyes and Their Analytical Applications[J]. Chinese Journal of Applied Chemistry, 2008, 25(9): 1017-1021.
某些酸性三苯甲烷染料与盐酸吡格列酮相互作用的分子光谱特点及其分析应用
摘要:
在不同pH值的Britton-Robinson缓冲溶液中,某些酸性三苯甲烷染料与盐酸吡格列酮反应,形成离子缔合物,其最大褪色波长在558~616 nm区间,最大吸收波长位于426~450 nm区间,盐酸吡格列酮的浓度在3.10×10-7~1.55×10-5 mol/L不同范围内遵守比耳定律,表观摩尔吸光系数分别在1.47×104~9.50×104 L/(mol·cm)内,检测限分别在0.033 2~0.257 mg/L内,建立了测定盐酸吡格列酮的光度法。方法有较高的灵敏度和良好的选择性,用于药品、血样、尿样中盐酸吡格列酮测定,结果满意。
English
Molecular Spectral Characters of Interaction of Pioglitazone Hydrolchloride with Some Acidic Triphenylmethane Dyes and Their Analytical Applications
Abstract:
In Britton-Robinson buffer media with different pH values,some acidic triphenylmethane dyes can form ion-association complexes with pioglitazone hydrolchloride respectively.The maximum fading wavelength of complexes is between 558 nm and 616 nm,and the maximum absorption wavelength is between 426 nm and 450 nm.The concentration of pioglitazone hydrolchloride follows Beer's law for the tight absorption in a range of 3.1×10-7 mol/L and 1.55×10-5 mol/L,the apparent molar absorptivity is between 1.47×104 L/(mol·cm) and 9.50×104 L/(mol·cm),and the detection limit is between 3.32×10-5 g/L and 2.57×10-4 g/L respectively.A sensitive spectrophotometric method is therefore developed for the determination of pioglitazone hydrolchloride.The method has a high sensitivity and a fairly good selectivity,and has been applied to the detemfination of pioglitazone hydrolchloride in urine samples,mixture samples and blood samples,with satisfactory results.
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