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Copper-catalyzed N-arylation of 2-arylindoles with aryl halides

Wei Liu ,  Li-Ya Han ,  Rui-Li Liu ,  Li-Ge Xu ,  Yan-Lan Bi

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Citation:  Wei Liu, Li-Ya Han, Rui-Li Liu, Li-Ge Xu, Yan-Lan Bi. Copper-catalyzed N-arylation of 2-arylindoles with aryl halides[J]. Chinese Chemical Letters, 2014, 25(9): 1240-1243. doi: 10.1016/j.cclet.2014.04.021 shu

Copper-catalyzed N-arylation of 2-arylindoles with aryl halides

    • 通讯作者: Wei Liu,
  • 基金项目:

    This work was supported by the National Natural Science Foundation of China (No. 21102036)  (No. 21102036)

    Plan for Scientific Innovation Talent of Henan University of Technology (No. 11CXRC02)  (No. 11CXRC02)

    startup fund from HAUT (No. 2010BS042). (No. 2010BS042)

摘要: 10 mol% CuI combined with the DMEDA ligand can efficiently catalyze the N-arylation of 2-arylindoles with aryl iodides and aryl bromides in good to excellent yields. The aryl halides bearing electron-rich or electron-deficient functional groups can be well tolerated under this mild reaction conditions.

English

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  • 收稿日期:  2014-03-28
  • 网络出版日期:  2014-04-14
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