6,7-<i>seco</i>-<i>ent</i>-Kaurane diterpenoids from Isodon <i>sculponeatus</i> and their bioactivity

注册 English

6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity

Hua-Yi Jiang , Wei-Guang Wang , Min Zhou , Hai-Yan Wu , Rui Zhan , Xue Du , Jian-Xin Pu , Han-Dong Sun

Citation: Hua-Yi Jiang, Wei-Guang Wang, Min Zhou, Hai-Yan Wu, Rui Zhan, Xue Du, Jian-Xin Pu, Han-Dong Sun. 6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity[J]. Chinese Chemical Letters, 2014, 25(4): 541-544. doi: 10.1016/j.cclet.2014.01.041 shu

shu

6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity

通讯作者: Jian-Xin Pu,
Han-Dong Sun,

摘要: One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC₅₀ values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC₅₀ value of 3.3 μmol/L.

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English

6,7-seco-ent-Kaurane diterpenoids from Isodon sculponeatus and their bioactivity

1.
a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;
2.
b University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: Jian-Xin Pu, Han-Dong Sun,

Received Date: 06 November 2013
Available Online: 31 January 2014

Abstract: One new 6,7-seco-ent-kaurane diterpenoid, sculponin T (1), was isolated from the aerial parts of Isodon sculponeatus, along with four known analogs, sculponeatin J (2), sculponeatin K (3), sculponeatin C (4), and sculponeatin Q (5). Their structures were elucidated by extensive spectroscopic analysis and by comparison with data reported in the literature. Significant cytotoxic activity was observed for compound 2 against five human tumor cell lines with IC₅₀ values ranging from 1.8 μmol/L to 3.3 μmol/L, and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with IC₅₀ value of 3.3 μmol/L.

Key words:

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