English

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Commun. 32 (2002) 3363-3366; (c) A.M. Shestopalov, Y.M. Emeliyanova, A.A. Shestopalov, et al., Cross-condensation of derivatives of cyanoacetic acid and carbonyl compounds. Part 1: Singlestage synthesis of 10-substituted 6-amino-spiro-4-(piperidine-40)-2H,4H-pyrano[ 2,3-c]pyrazole-5-carbonitriles, Tetrahedron 59 (2003) 7491-7496; (d) D.Q. Shi, J. Mou, Q.Y. Zhuang, et al., Three-component one-pot synthesis of 1, 4-dihydropyrano[2,3-c]pyrazole derivatives in aqueous Media, Synth. Commun. 34 (2004) 4557-4563; (e) T.S. Jin, A.Q. Wang, Z.L. Cheng, J.S. Zhang, T.S. Li, A clean and simple synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole in water, Synth. Commun. 35 (2005) 137-143; (f) Z.J. Ren, W.G. Cao, W.Q. Tong, Z. Jin, Solvent-free, one-pot synthesis of pyrano[2,3-c]pyrazole derivatives in the presence of KF 2H₂O by Grinding, Synth. Commun. 35 (2005) 2509-2513; (g) Y.Q. Peng, G.H. Song, R.L. Dou, Surface cleaning under combined microwave and ultrasound irradiation: flash synthesis of 4H-pyrano[2,3-c]pyrazoles in aqueous media, Green Chem. 8 (2006) 573-575; (h) F. Lehmann, M. Holm, S. Laufer, Three-component combinatorial synthesis of novel dihydropyrano[2,3-c]pyrazoles, J. Comb. Chem. 10 (2008) 364-367; (i) H. Sheibani, M. Babaie, Three-component reaction to form 1,4-dihydropyrano[ 2,3-c]pyrazol-5-yl cyanides, Synth. Commun. 40 (2009) 257-265; (j) A.S. Nagarajan, B.S.R. Reddy, Synthesis of substituted pyranopyrazoles under neat conditions via a multicomponent reaction, Synlett (2009) 2002-2004; (k) Y.M. Litvinov, A.A. Shestopalov, L.A. Rodinovskaya, A.M. Shestopalov, New convenient four-component synthesis of 6-amino-2,4-dihydropyrano[2,3-c]pyrazol- 5-carbonitriles and one-pot synthesis of 60-aminospiro[(3H)-indol-3,40-pyrano[ 2,3-c]pyrazol]-(1H)-2-on-50-carbonitriles, J. Comb. Chem. 11 (2009) 914-919; (l) R. Balaskar, S. Gavade, D. Mane, Greener approach towards the facile synthesis of 1,4-dihydropyrano[2,3-c]pyrazol-5-yl cyanide derivatives at room temperature, Chin. Chem. Lett. 21 (2010) 1175-1179; (m) H. Mecadon, M.R. Rohman, I. Kharbangar, et al., l-Proline as an efficient catalyst for the multi-component synthesis of 6-amino-4-alkyl/aryl-3- methyl- 2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in water, Tetrahedron Lett. 52 (2011) 3228-3231.

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  10. [10] (a) E. Maalej, F. Chabchoub, A. Samadi, et al., Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[ 2,3-b]quinolin-13-amines, Bioorg. Med. Chem. Lett. 21 (2011) 2384-2388; (b) N.P. Selvam, T.H. Babu, P.T. Perumal, A simple and convenient approach to the Friedländer synthesis of pyrano[2,3-b]pyridines, Tetrahedron 65 (2009) 8524-8530; (c) J.R. Li, L.J. Zhang, D.X. Shi, et al., A new conversion of Friedla¨ndler reaction and the structure of its products, Synlett (2008) 233-236.[10] (a) E. Maalej, F. Chabchoub, A. Samadi, et al., Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[ 2,3-b]quinolin-13-amines, Bioorg. Med. Chem. Lett. 21 (2011) 2384-2388; (b) N.P. Selvam, T.H. Babu, P.T. Perumal, A simple and convenient approach to the Friedländer synthesis of pyrano[2,3-b]pyridines, Tetrahedron 65 (2009) 8524-8530; (c) J.R. Li, L.J. Zhang, D.X. Shi, et al., A new conversion of Friedla¨ndler reaction and the structure of its products, Synlett (2008) 233-236.

  11. [11] X-ray crystal: Triclinic, space group: P-1, Final R indices [I>2sigma(I)]: R₁ = 0.0537, wR₂ = 0.1763; unit cell dimensions: a = 7.6593(12) Å, b = 13.191(2) Å, c = 13.678 (2)Å, α = 67.787(2)8, β = 82.977(3)8, γ = 86.498(2)8; volume: 1269.7(3) ų; crystal size: 0.39 mm×0.30 mm×0.28 mm; T = 173(2) K; Z, calculated density: 2, 1.416 mg/m3; reflections collected/unique: 9139/5448[R(int) = 0.0219]; date/restraints/parameters: 5448/0/316. X-ray analysis of single crystal of 5 was deposited at Cambridge crystallographic data center with CCDC 862430.[11] X-ray crystal: Triclinic, space group: P-1, Final R indices [I>2sigma(I)]: R₁ = 0.0537, wR₂ = 0.1763; unit cell dimensions: a = 7.6593(12) Å, b = 13.191(2) Å, c = 13.678 (2)Å, α = 67.787(2)8, β = 82.977(3)8, γ = 86.498(2)8; volume: 1269.7(3) ų; crystal size: 0.39 mm×0.30 mm×0.28 mm; T = 173(2) K; Z, calculated density: 2, 1.416 mg/m3; reflections collected/unique: 9139/5448[R(int) = 0.0219]; date/restraints/parameters: 5448/0/316. X-ray analysis of single crystal of 5 was deposited at Cambridge crystallographic data center with CCDC 862430.

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  13. [13] (a) G. Kolokythas, N. Pouli, P. Marakos, H. Pratsinis, D. Kletsas, Synthesis and antiproliferative activity of some new azapyranoxanthenone amino derivatives, Eur. J. Med. Chem. 41 (2006) 71-79; (b) M.A. Azuine, H. Tokuda, J. Takayasu, et al., Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol- 13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models, Pharmacol. Res. 49 (2004) 161-169; (c) S.K. Srivastava, R.P. Tripathi, R. Ramachandran, NAD⁺-dependent DNA ligase (rv3014c) from mycobacterium tuberculosis: crystal structure of the adenylation domain and identification of novel inhibitors, J. Biol. Chem. 280 (2005) 30273- 30281; (d) H. Brotz-Oesterhelt, I. Knezevic, S. Bartel, et al., Specific and potent inhibition of NAD⁺-dependent DNA ligase by pyridochromanones, J. Biol. Chem. 278 (2003) 39435-39442.[13] (a) G. Kolokythas, N. Pouli, P. Marakos, H. Pratsinis, D. Kletsas, Synthesis and antiproliferative activity of some new azapyranoxanthenone amino derivatives, Eur. J. Med. Chem. 41 (2006) 71-79; (b) M.A. Azuine, H. Tokuda, J. Takayasu, et al., Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol- 13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models, Pharmacol. Res. 49 (2004) 161-169; (c) S.K. Srivastava, R.P. Tripathi, R. Ramachandran, NAD⁺-dependent DNA ligase (rv3014c) from mycobacterium tuberculosis: crystal structure of the adenylation domain and identification of novel inhibitors, J. Biol. Chem. 280 (2005) 30273- 30281; (d) H. Brotz-Oesterhelt, I. Knezevic, S. Bartel, et al., Specific and potent inhibition of NAD⁺-dependent DNA ligase by pyridochromanones, J. Biol. Chem. 278 (2003) 39435-39442.

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