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Amplified ultraviolet detection of natural DNA based on Mo6S9-xIx nanowires

Hong Lin ,  Mei-Xian Li ,  Fei Liu ,  Dragan Mihailovič

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Citation:  Hong Lin, Mei-Xian Li, Fei Liu, Dragan Mihailovič. Amplified ultraviolet detection of natural DNA based on Mo6S9-xIx nanowires[J]. Chinese Chemical Letters, 2014, 25(4): 645-648. doi: 10.1016/j.cclet.2013.11.032 shu

Amplified ultraviolet detection of natural DNA based on Mo6S9-xIx nanowires

    • 通讯作者: Hong Lin,
  • 基金项目:

    This project was supported by the National Natural Science Foundation of China (No. 20875005). (No. 20875005)

摘要: We demonstrate that Mo6S9-xIx nanowires (MoSI NWs) can serve as an excellent signal-intensifying nanomaterial for highly sensitive and label-free detection of DNA by ultraviolet (UV) spectrophotometry. The DNA extinction at 260 nm was greatly enhanced after addition of MoSI NWs solute, and the extinction value was linear with DNA concentration in the range of 0.0289-11.68 μg/mL with the real determination limit of 28.9 ng/mL. The association of DNA with the nanowires was characterized by transmission electronmicroscopy and circular dichroic spectroscopy. The results illustrate that the UV response amplification of DNA in the presence of MoSI NWs is attributed to the greater DNA coverage on the MoSINWsurface and the conformational transformation of DNA due to interaction of DNA with MoSI NWs. MoSI NWs are a promising nano-structured material for developing ultrasensitive sensors for detection of DNA.

English

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  • 发布日期:  2013-11-26
  • 收稿日期:  2013-09-22
  • 网络出版日期:  2013-11-12
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