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Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence

Mahdi Parvar ,  Jalil Mehrzad ,  Mohammad Javad Chaichi ,  Saman Hosseinkhani ,  Hamid Golchoubian

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Citation:  Mahdi Parvar, Jalil Mehrzad, Mohammad Javad Chaichi, Saman Hosseinkhani, Hamid Golchoubian. Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence[J]. Chinese Chemical Letters, 2014, 25(4): 630-634. doi: 10.1016/j.cclet.2014.01.022 shu

Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence

    • 通讯作者: Jalil Mehrzad,
  • 基金项目:

    The authors gratefully acknowledge the bureau (area) for research  (area)

摘要: Removing excessive free radicals (FRs) by a synthetic chemical might give a clue for treatment of many iron-mediated diseases. Deferoxamine (DFO) can be one of the chemicals of choice for the clue. To investigate photoredox properties of DFO, its quenching effect on superoxide radical (O2-·), hydrogen peroxide (H2O2) and hydroxyl radical (OH·) was examined using luminol and ortho-phenanthroline (o-phen) chemiluminescence (CL) systems and UV-vis spectrophotometry. Stern-Volmer equation was also used for the CL kinetics. The observed quenching effect of DFO on CL/photon production in luminol and o-phen CL systems strongly confirmed the static arm of quenching properties of DFO on OH· and H2O2, but much less pronounced on O2-·; the quenching property wasmaximal when iron was involved in the reaction systems. The Stern-Volmer plots in the designed photochemical reaction systems also confirmed a potent quenching effect of DFO on FR-mediated CL. Our study highlights strong photoreducing and antioxidant properties of DFO with huge quenching capacity on excessive FRs, and thus implies its promising prospects for therapeutic applications.

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    1. [1] J. Mehrzad, H. Dosogne, E. Meyer, R. Heyneman, C. Burvenich, Respiratory burst activity of blood and milk neutrophils in dairy cows during different stages of lactation, J. Dairy Res. 68 (2001) 399-415.[1] J. Mehrzad, H. Dosogne, E. Meyer, R. Heyneman, C. Burvenich, Respiratory burst activity of blood and milk neutrophils in dairy cows during different stages of lactation, J. Dairy Res. 68 (2001) 399-415.

    2. [2] J. Mehrzad, L. Duchateau, C. Burvenich, High milk neutrophil chemiluminescence limits the severity of bovine coliform mastitis, Vet. Res. 36 (2005) 101-116.[2] J. Mehrzad, L. Duchateau, C. Burvenich, High milk neutrophil chemiluminescence limits the severity of bovine coliform mastitis, Vet. Res. 36 (2005) 101-116.

    3. [3] S. Dikalov, K.K. Griendling, D.G. Harrison, Measurement of reactive oxygen species in cardiovascular studies, Hypertension 49 (2007) 717-727.[3] S. Dikalov, K.K. Griendling, D.G. Harrison, Measurement of reactive oxygen species in cardiovascular studies, Hypertension 49 (2007) 717-727.

    4. [4] K. Takeshige, S. Minakami, NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation, Biochem. J. 180 (1979) 129-135.[4] K. Takeshige, S. Minakami, NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation, Biochem. J. 180 (1979) 129-135.

    5. [5] B. Halliwell, J.M. Gutteridge, Role of free radicals and catalytic metal ions in human disease: an overview, Methods Enzymol. 186 (1990) 1-85.[5] B. Halliwell, J.M. Gutteridge, Role of free radicals and catalytic metal ions in human disease: an overview, Methods Enzymol. 186 (1990) 1-85.

    6. [6] C.W. Trenam, D.R. Blake, C.J. Morris, Skin inflammation: reactive oxygen species and the role of iron, J. Invest. Dermatol. 99 (1992) 675-682.[6] C.W. Trenam, D.R. Blake, C.J. Morris, Skin inflammation: reactive oxygen species and the role of iron, J. Invest. Dermatol. 99 (1992) 675-682.

    7. [7] G. Poli, U. Leonarduzzi, F. Biasi, E. Chiarpotto, Oxidative stress and cell signaling, Curr. Med. Chem. 11 (2004) 1163-1182.[7] G. Poli, U. Leonarduzzi, F. Biasi, E. Chiarpotto, Oxidative stress and cell signaling, Curr. Med. Chem. 11 (2004) 1163-1182.

    8. [8] J.E. Schneider, M.M. Browning, X. Zhu, K.L. Eneff, R.A. Floyd, Characterization of hydroxyl free radical mediated damage to plasmid pBR322 DNA, Mutat. Res. 214 (1989) 23-31.[8] J.E. Schneider, M.M. Browning, X. Zhu, K.L. Eneff, R.A. Floyd, Characterization of hydroxyl free radical mediated damage to plasmid pBR322 DNA, Mutat. Res. 214 (1989) 23-31.

    9. [9] E.R. Stadtman, B.S. Berlett, Reactive-oxygen mediated protein oxidation in aging and disease, Chem. Res. Toxicol. 10 (1997) 485-494.[9] E.R. Stadtman, B.S. Berlett, Reactive-oxygen mediated protein oxidation in aging and disease, Chem. Res. Toxicol. 10 (1997) 485-494.

    10. [10] H.J.H. Fenton, Oxidation of tartaric acid in the presence of iron, J. Chem. Soc. 65 (1894) 899-910.[10] H.J.H. Fenton, Oxidation of tartaric acid in the presence of iron, J. Chem. Soc. 65 (1894) 899-910.

    11. [11] E. Neyens, J. Baeyens, A review of classic Fenton's peroxidation as an advanced oxidation technique, J. Hazard. Mater. 98 (2003) 33-50.[11] E. Neyens, J. Baeyens, A review of classic Fenton's peroxidation as an advanced oxidation technique, J. Hazard. Mater. 98 (2003) 33-50.

    12. [12] S.B. Wang, A comparative study of Fenton and Fenton-like reaction kinetics in decolourisation of wastewater, Dyes Pigments 76 (2008) 714-720.[12] S.B. Wang, A comparative study of Fenton and Fenton-like reaction kinetics in decolourisation of wastewater, Dyes Pigments 76 (2008) 714-720.

    13. [13] F. Haber, J. Weiss, The catalytic decomposition of hydrogen peroxide by iron salts, Proc. R. Soc. Lond. A 147 (1934) 332-351.[13] F. Haber, J. Weiss, The catalytic decomposition of hydrogen peroxide by iron salts, Proc. R. Soc. Lond. A 147 (1934) 332-351.

    14. [14] B. Halliwell, Free-radicals, antioxidants, and human disease: curiosity, cause, or consequences, Lancet 344 (1994) 721-724.[14] B. Halliwell, Free-radicals, antioxidants, and human disease: curiosity, cause, or consequences, Lancet 344 (1994) 721-724.

    15. [15] M. Auer, L.A. Pfister, D. Leppert, M.G. Taüber, S.L. Leib, Effects of clinically used antioxidants in experimental pneumococcal meningitis, J. Infect. Dis. 182 (2000) 347-350.[15] M. Auer, L.A. Pfister, D. Leppert, M.G. Taüber, S.L. Leib, Effects of clinically used antioxidants in experimental pneumococcal meningitis, J. Infect. Dis. 182 (2000) 347-350.

    16. [16] I. Paterniti, E. Mazzon, E. Emanuela, et al., Modulation of inflammatory response after spinal cord trauma with deferoxamine, an iron chelator, Free Radic. Res. 44 (2010) 694-699.[16] I. Paterniti, E. Mazzon, E. Emanuela, et al., Modulation of inflammatory response after spinal cord trauma with deferoxamine, an iron chelator, Free Radic. Res. 44 (2010) 694-699.

    17. [17] E.M. Hoke, C.A. Maylock, E. Shacter, Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin, Free Radic. Biol. Med. 39 (2005) 403-411.[17] E.M. Hoke, C.A. Maylock, E. Shacter, Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin, Free Radic. Biol. Med. 39 (2005) 403-411.

    18. [18] E. Banin, A. Lozinski, K.M. Brady, et al., The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent, Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 16761-16766.[18] E. Banin, A. Lozinski, K.M. Brady, et al., The potential of desferrioxamine-gallium as an anti-Pseudomonas therapeutic agent, Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 16761-16766.

    19. [19] C.L. Tielemans, C.M. Lenclud, R. Wens, F.E. Collart, M. Dratwa, Critical role of iron overload in the increased susceptibility of haemodialysis patients to bacterial infections. Beneficial effects of desferrioxamine, Nephrol. Dial. Transplant. 4 (1989) 883-887.[19] C.L. Tielemans, C.M. Lenclud, R. Wens, F.E. Collart, M. Dratwa, Critical role of iron overload in the increased susceptibility of haemodialysis patients to bacterial infections. Beneficial effects of desferrioxamine, Nephrol. Dial. Transplant. 4 (1989) 883-887.

    20. [20] O. Cozar, N. Leopold, C. Jelic, et al., IR, Raman and surface-enhanced Raman study of desferrioxamine B and its Fe(ⅡI) complex, ferrioxamine B, J. Mol. Struct. 788 (2006) 1-6.[20] O. Cozar, N. Leopold, C. Jelic, et al., IR, Raman and surface-enhanced Raman study of desferrioxamine B and its Fe(ⅡI) complex, ferrioxamine B, J. Mol. Struct. 788 (2006) 1-6.

    21. [21] S. Singh, R.C. Hider, J.B. Porter, Separation and identification of desferrioxamine and its iron chelating metabolites by high performance liquid chromatography and fast atom bombardment mass spectrometry: choice of complexing agent and application to biological fluids, Anal. Biochem. 187 (1990) 212-219.[21] S. Singh, R.C. Hider, J.B. Porter, Separation and identification of desferrioxamine and its iron chelating metabolites by high performance liquid chromatography and fast atom bombardment mass spectrometry: choice of complexing agent and application to biological fluids, Anal. Biochem. 187 (1990) 212-219.

    22. [22] E. Farkas, H. Csóka, G. Micera, A. Dessi, Copper(Ⅱ), nickel(Ⅱ), zinc(Ⅱ), and molybdenum( VI) complexes of desferrioxamine B in aqueous solution, J. Inorg. Biochem. 65 (1997) 281-286.[22] E. Farkas, H. Csóka, G. Micera, A. Dessi, Copper(Ⅱ), nickel(Ⅱ), zinc(Ⅱ), and molybdenum( VI) complexes of desferrioxamine B in aqueous solution, J. Inorg. Biochem. 65 (1997) 281-286.

    23. [23] I. Parejo, C. Petrakis, P. Kefalas, A transition metal enhanced luminol chemiluminescence in the presence of a chelator, J. Pharmacol. Toxicol. 43 (2000) 183-190.[23] I. Parejo, C. Petrakis, P. Kefalas, A transition metal enhanced luminol chemiluminescence in the presence of a chelator, J. Pharmacol. Toxicol. 43 (2000) 183-190.

    24. [24] M. Shamsipur, M.J. Chaichi, A study of quenching effect of sulfur-containing amino acids L-cysteine and L-methionine on peroxyoxalate chemiluminescence of 7-amino-4-trifluoromethylcumarin, Spectrochim. Acta A: Mol. Biomol. Spectrosc. 61 (2005) 1227-1231.[24] M. Shamsipur, M.J. Chaichi, A study of quenching effect of sulfur-containing amino acids L-cysteine and L-methionine on peroxyoxalate chemiluminescence of 7-amino-4-trifluoromethylcumarin, Spectrochim. Acta A: Mol. Biomol. Spectrosc. 61 (2005) 1227-1231.

    25. [25] Y.J. Hua, I. Narumi, G.J. Gao, et al., PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans, Biochem. Biophys. Res. Commun. 306 (2003) 354-360.[25] Y.J. Hua, I. Narumi, G.J. Gao, et al., PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans, Biochem. Biophys. Res. Commun. 306 (2003) 354-360.

    26. [26] B. Tian, Y. Wu, D. Sheng, et al., Chemiluminescence assay for reactive oxygen species scavenging activities and inhibition on oxidative damage of DNA in Deinococcus radiodurans, Luminescence 19 (2004) 78-84.[26] B. Tian, Y. Wu, D. Sheng, et al., Chemiluminescence assay for reactive oxygen species scavenging activities and inhibition on oxidative damage of DNA in Deinococcus radiodurans, Luminescence 19 (2004) 78-84.

    27. [27] Y. Zhao, W. Yu, D. Wang, X. Liang, T. Hu, Chemiluminescence determination of free radical scavenging abilities of ‘tea pigments' and comparison with ‘tea polyphenols', Food Chem. 80 (2003) 115-118.[27] Y. Zhao, W. Yu, D. Wang, X. Liang, T. Hu, Chemiluminescence determination of free radical scavenging abilities of ‘tea pigments' and comparison with ‘tea polyphenols', Food Chem. 80 (2003) 115-118.

    28. [28] C. Xiao, D.A. Palmer, D.J. Wesolowski, S.B. Lovitz, W. King, Carbon dioxide effects on luminol and 1,10-phenanthroline chemiluminescence, Anal. Chem. 74 (2002) 2210-2216.[28] C. Xiao, D.A. Palmer, D.J. Wesolowski, S.B. Lovitz, W. King, Carbon dioxide effects on luminol and 1,10-phenanthroline chemiluminescence, Anal. Chem. 74 (2002) 2210-2216.

    29. [29] L. Magnania, E.M. Gaydoua, J.C. Hubaud, Spectrophotometric measurement of antioxidant properties of flavones and flavonols against superoxide anion, Anal. Chim. Acta 411 (2000) 209-216.[29] L. Magnania, E.M. Gaydoua, J.C. Hubaud, Spectrophotometric measurement of antioxidant properties of flavones and flavonols against superoxide anion, Anal. Chim. Acta 411 (2000) 209-216.

    30. [30] T. Sun, Z.D. Xu, Radical scavenging activities of a-alanine C60 adduct, Bioorg. Med. Chem. Lett. 16 (2006) 3731-3734.[30] T. Sun, Z.D. Xu, Radical scavenging activities of a-alanine C60 adduct, Bioorg. Med. Chem. Lett. 16 (2006) 3731-3734.

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  • 发布日期:  2014-01-14
  • 收稿日期:  2013-07-19
  • 网络出版日期:  2013-12-24
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