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Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence

Mahdi Parvar ,  Jalil Mehrzad ,  Mohammad Javad Chaichi ,  Saman Hosseinkhani ,  Hamid Golchoubian

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Citation:  Mahdi Parvar, Jalil Mehrzad, Mohammad Javad Chaichi, Saman Hosseinkhani, Hamid Golchoubian. Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence[J]. Chinese Chemical Letters, 2014, 25(4): 630-634. doi: 10.1016/j.cclet.2014.01.022 shu

Quenching effect of deferoxamine on free radical-mediated photon production in luminol and ortho-phenanthroline-dependent chemiluminescence

    • 通讯作者: Jalil Mehrzad,
  • 基金项目:

    The authors gratefully acknowledge the bureau (area) for research  (area)

摘要: Removing excessive free radicals (FRs) by a synthetic chemical might give a clue for treatment of many iron-mediated diseases. Deferoxamine (DFO) can be one of the chemicals of choice for the clue. To investigate photoredox properties of DFO, its quenching effect on superoxide radical (O2-·), hydrogen peroxide (H2O2) and hydroxyl radical (OH·) was examined using luminol and ortho-phenanthroline (o-phen) chemiluminescence (CL) systems and UV-vis spectrophotometry. Stern-Volmer equation was also used for the CL kinetics. The observed quenching effect of DFO on CL/photon production in luminol and o-phen CL systems strongly confirmed the static arm of quenching properties of DFO on OH· and H2O2, but much less pronounced on O2-·; the quenching property wasmaximal when iron was involved in the reaction systems. The Stern-Volmer plots in the designed photochemical reaction systems also confirmed a potent quenching effect of DFO on FR-mediated CL. Our study highlights strong photoreducing and antioxidant properties of DFO with huge quenching capacity on excessive FRs, and thus implies its promising prospects for therapeutic applications.

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  • 发布日期:  2014-01-14
  • 收稿日期:  2013-07-19
  • 网络出版日期:  2013-12-24
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