A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance

Davood Nematollahi Saied Saeed Hosseiny Davarani Pari Mirahmadpour Fahimeh Varmaghani

Citation:  Davood Nematollahi, Saied Saeed Hosseiny Davarani, Pari Mirahmadpour, Fahimeh Varmaghani. A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance[J]. Chinese Chemical Letters, 2014, 25(4): 593-595. doi: 10.1016/j.cclet.2014.01.005 shu

A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biological significance

    通讯作者: Davood Nematollahi,
  • 基金项目:

    Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS) for their support of this work. (CEDEFMCS)

摘要: The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2,3-dihydrophthalazine-1,4-dione (1) in the presence of arylsulfinic acids (2a and 2b) as nucleophiles. The results show that, the electrogenerated phthalazine-1,4-dione (1ox) participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives. This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.

English

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  • 发布日期:  2014-01-09
  • 收稿日期:  2013-07-29
  • 网络出版日期:  2013-12-26
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