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N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用

韩向斌 ,  邵颖 ,  沈永淼

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引用本文: 韩向斌, 邵颖, 沈永淼. N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用[J]. 无机化学学报, 2013, 29(12): 2643-2648. doi: 10.3969/j.issn.1001-4861.2013.00.400 shu
Citation:  HAN Xiang-Bin, SHAO Ying, SHEN Yong-Miao. Synthesis, Crystal Structure and DNA-Binding Properties of Binuclear Copper(Ⅱ) Complex with N-Phthaloylglycinate[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(12): 2643-2648. doi: 10.3969/j.issn.1001-4861.2013.00.400 shu

N-邻苯二甲酰甘氨酸双核铜(Ⅱ)配合物的合成、晶体结构及与DNA的作用

  • 基金项目:

    浙江省自然科学基金(No.Y508308) (No.Y508308)

    江苏省新型环保重点实验室(No.AE201306)资助项目。 (No.AE201306)

摘要: 合成了新的双核铜(Ⅱ)配合物：[Cu2(DMSO)2(ODPA)4]·2DMSO(其中，DMSO=二甲基亚砜，ODPA=N-邻苯二甲酰甘氨酸)。通过X-射线单晶衍射测定了该配合物的结构。配合物晶体属于三斜晶系，空间群P1，晶胞参数：a=1.036 1(2) nm，b=1.127 3(2) nm，c=1.212 6(2) nm，α=84.084(2)°，β=81.765(3)°，γ=82.163(2)°；晶胞体积V=1.383 6(4) nm3，晶胞结构基元数Z=1，Dc=1.508 g·cm-3，最后的残差因子：R=0.075 0，wR2=0.192 7。用紫外和荧光光谱等方法研究了配合物与DNA的相互作用。结果表明，配合物以部分插入方式与DNA作用，凝胶电泳实验结果表明，该配合物能够切割pBR322 DNA成Form Ⅱ。

English

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    1. [1] LIU Jing-Gang (刘劲刚), JI Nian-Liang (计亮年). Chinese. J. Inorg. Chem. (Wuji Huaxue Xuebao), 2000, 16 (2):195-203[1] LIU Jing-Gang (刘劲刚), JI Nian-Liang (计亮年). Chinese. J. Inorg. Chem. (Wuji Huaxue Xuebao), 2000, 16 (2):195-203

    2. [2] Garoufis A, Hadjikakou S K, Hadjiliadis N. Coord. Chem. Rev., 2009, 253 (9-10):1384-1397[2] Garoufis A, Hadjikakou S K, Hadjiliadis N. Coord. Chem. Rev., 2009, 253 (9-10):1384-1397

    3. [3] Patra A K, Roy S, Chakravarty A R. Inorg. Chem. Acta, 2009, 362 (13):4692-4698[3] Patra A K, Roy S, Chakravarty A R. Inorg. Chem. Acta, 2009, 362 (13):4692-4698

    4. [4] Grueso E, Ló pez-Pé rez G, Castellano M, et al. Inorg. Biochem., 2012, 106 (1):1-9[4] Grueso E, Ló pez-Pé rez G, Castellano M, et al. Inorg. Biochem., 2012, 106 (1):1-9

    5. [5] Bencini A, Lippolis V. Coord. Chem. Rev., 2010, 254 (17/18): 2096-2180[5] Bencini A, Lippolis V. Coord. Chem. Rev., 2010, 254 (17/18): 2096-2180

    6. [6] Serganov A, Patel D J. Sequence Specific DNA Binding Agents. Cambridge: Royal Society of Chemistry, 2006:233-252[6] Serganov A, Patel D J. Sequence Specific DNA Binding Agents. Cambridge: Royal Society of Chemistry, 2006:233-252

    7. [7] Zelenak V, Gyoryova K, Mlynarcik D. Metal-Based Drugs, 2002, 8:269-274[7] Zelenak V, Gyoryova K, Mlynarcik D. Metal-Based Drugs, 2002, 8:269-274

    8. [8] Arshad N, Abbas N, Bhatti M H, et al. J. Photoch. Photobio. B, 2012, 117:228-239[8] Arshad N, Abbas N, Bhatti M H, et al. J. Photoch. Photobio. B, 2012, 117:228-239

    9. [9] Antunes R, Batista H, Srivastava R M, et al. Bioorg. Med. Chem. Lett., 1998, 8:3071-3076[9] Antunes R, Batista H, Srivastava R M, et al. Bioorg. Med. Chem. Lett., 1998, 8:3071-3076

    10. [10] Ng S W, Kuthubutheen A J, Das V G K, et al. Appl. Organomet. Chem., 1994, 8:37-42[10] Ng S W, Kuthubutheen A J, Das V G K, et al. Appl. Organomet. Chem., 1994, 8:37-42

    11. [11] Linsday V N G, Wei L, Charette A B. J. Am. Chem. Soc., 2009, 131:16383-16385[11] Linsday V N G, Wei L, Charette A B. J. Am. Chem. Soc., 2009, 131:16383-16385

    12. [12] XU Han (徐涵), LI Yi-Zhi (李一志), BAI Jun-Feng (白俊峰), J. Synthetic Crystals (Rengong Jingti Xuebao), 2009, 38:1022-1026[12] XU Han (徐涵), LI Yi-Zhi (李一志), BAI Jun-Feng (白俊峰), J. Synthetic Crystals (Rengong Jingti Xuebao), 2009, 38:1022-1026

    13. [13] WANG Hui (王慧), GAN Guo-Qing (甘国庆), ZHAI Yang (翟 阳), et al. Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012, 28 (6):1217-1221[13] WANG Hui (王慧), GAN Guo-Qing (甘国庆), ZHAI Yang (翟 阳), et al. Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012, 28 (6):1217-1221

    14. [14] Marmur J. J. Mol. Biol., 1961, 3:208-221[14] Marmur J. J. Mol. Biol., 1961, 3:208-221

    15. [15] Reichmann M E, Rice S A, Thomas C A, et al. J. Am. Chem. Soc., 1954, 76:3047-3053[15] Reichmann M E, Rice S A, Thomas C A, et al. J. Am. Chem. Soc., 1954, 76:3047-3053

    16. [16] SADABS. Empirical Absorption Correction Program, University of Göttingen, Göttingen, Germany, 1997.[16] SADABS. Empirical Absorption Correction Program, University of Göttingen, Göttingen, Germany, 1997.

    17. [17] Sheldrick G M. Acta Cryst., 2008, A64:112-122[17] Sheldrick G M. Acta Cryst., 2008, A64:112-122

    18. [18] Grigg R, Gunaratne H Q N, Sridharan V. J. Chem. Soc., Chem. Commun., 1985:1183-1185[18] Grigg R, Gunaratne H Q N, Sridharan V. J. Chem. Soc., Chem. Commun., 1985:1183-1185

    19. [19] Fomina I, Dobrokhotova Z, Aleksandrov G, et al. Polyhedron, 2010, 29:1734-1746[19] Fomina I, Dobrokhotova Z, Aleksandrov G, et al. Polyhedron, 2010, 29:1734-1746

    20. [20] Iqbal M, Ahmad I, Alia S, et al. Polyhedron, 2013, 50:524-531[20] Iqbal M, Ahmad I, Alia S, et al. Polyhedron, 2013, 50:524-531

    21. [21] Wolf A, Jr Shimer G H, Meehan T. Biochemistry, 1987, 26 (20):6392-6396[21] Wolf A, Jr Shimer G H, Meehan T. Biochemistry, 1987, 26 (20):6392-6396

    22. [22] ZHANG Xue-Mei (张雪梅), QU Zhi-Bin (区志镔), CHEN Shi (陈实). Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012, 28 (12):2667-2673[22] ZHANG Xue-Mei (张雪梅), QU Zhi-Bin (区志镔), CHEN Shi (陈实). Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012, 28 (12):2667-2673

    23. [23] Lakowicz J R, Webber G. Biochemistry, 1973, 12 (21):4161-4170[23] Lakowicz J R, Webber G. Biochemistry, 1973, 12 (21):4161-4170

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  • 收稿日期:  2013-05-21
  • 网络出版日期:  2013-07-30
通讯作者: 陈斌, bchen63@163.com
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