抗抑郁化合物SIPI5358与环糊精形成的非共价复合物

引用本文: 何小丹, 姜丹, 陈琛, 储艳秋, 丁传凡, 翁志洁, 李建其. 抗抑郁化合物SIPI5358与环糊精形成的非共价复合物[J]. 物理化学学报, 2010, 26(10): 2604-2612. doi: 10.3866/PKU.WHXB20100911 shu

Citation: HE Xiao-Dan, JIANG Dan, CHEN Chen, CHU Yan-Qiu, DING Chuan-Fan, WENG Zhi-Jie, LI Jian-Qi. Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins[J]. Acta Physico-Chimica Sinica, 2010, 26(10): 2604-2612. doi: 10.3866/PKU.WHXB20100911 shu

抗抑郁化合物SIPI5358与环糊精形成的非共价复合物

何小丹 ^1, ,
姜丹 ^1, ,
陈琛 ^1, ,
储艳秋 ^1, ,
丁传凡 ^1, ,
翁志洁 ^2, ,
李建其 ^2,

基金项目:
国家自然科学基金(30772623) (30772623)

国家十一五项目重大新药创制(2009ZX09103-047)资助项目 (2009ZX09103-047)

摘要:

用电喷雾电离质谱(ESI -MS) 和串级质谱(MS/MS), 并结合紫外光谱、荧光光谱等方法, 研究一种芳烷醇哌嗪类抗抑郁化合物SIPI5358 与α-、β-、γ-环糊精(CD) 制备得到的非共价复合物. 质谱分析结果显示, SIPI5358 分子可以和α-CD 生成配合比为1:1 的非共价复合物, 而与β-、γ-CD 生成不同配合比的非共价复合物. 串级质谱的结果进一步验证β-CD 与SIPI5358 非共价复合物的组成. 用紫外光谱和荧光光谱实验对液相中非共价复合物的形成进行了辅助研究, 结果均再次验证了非共价复合物的生成. 荧光光谱实验测得SIPI5358 与β-CD 反应的生成常数K_f=3.45 ×10³mol·L^-1.

关键词:

English

Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins

1.
1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of Laser Chemistry, Department of Chemistry, Fudan University, Shanghai 200433, P. R. China;
2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, P. R. China
Received Date: 05 March 2010
Available Online: 27 September 2010
Fund Project:
国家自然科学基金(30772623)

国家十一五项目重大新药创制(2009ZX09103-047)资助项目

Abstract:

Non-covalent complexes of α-, β-, and γ-cyclodextrin (CD) with the antidepressant compound SIPI5358 were investigated by electrospray ionization mass spectrometry (ESI-MS), tandem mass spectrometry (MS/MS), UV spectroscopy, and fluorescence spectroscopy. The ESI-MS experimental results revealed that SIPI5358 reacted with the α-, β-, and γ-CD to form complexes with different coordination numbers. The tandem mass spectra further confirmed the formation of non-covalent complexes of SIPI5358 with β-CD. Binding of the complexes was also confirmed by UV as well as fluorescence spectra. The formation constant K_f was determined by fluorescence spectroscopy to be 3.45 ×10³mol·L^-1for the complex of SIPI5358 and β-CD.

Key words:

Cyclodextrin
/ Antidepressant
/ Non-covalent complex
/ UV spectroscopy
/ Electrospray ionization mass spectrometry
/ Fluorescence spectroscopy

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

抗抑郁化合物SIPI5358与环糊精形成的非共价复合物

English

Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

抗抑郁化合物SIPI5358与环糊精形成的非共价复合物

English

Non-Covalent Complexes of the Antidepressant Compound SIPI5358 with Cyclodextrins

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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