引用本文:
郭明, 严建伟, 俞庆森, 商志才, 吕建德. 加替沙星与牛血清白蛋白的结合反应研究[J]. 物理化学学报,
2004, 20(02): 202-206.
doi:
10.3866/PKU.WHXB20040220
Citation: Guo Ming, Yan Jian-Wei, Yu Qing-Sen, Shang Zhi-Cai, Lü Jian-De. Characterization of Interaction between Gatifloxacin and Bovine Serum Albumin[J]. Acta Physico-Chimica Sinica, 2004, 20(02): 202-206. doi: 10.3866/PKU.WHXB20040220
Citation: Guo Ming, Yan Jian-Wei, Yu Qing-Sen, Shang Zhi-Cai, Lü Jian-De. Characterization of Interaction between Gatifloxacin and Bovine Serum Albumin[J]. Acta Physico-Chimica Sinica, 2004, 20(02): 202-206. doi: 10.3866/PKU.WHXB20040220
加替沙星与牛血清白蛋白的结合反应研究
摘要:
应用简化的Hummel-Dreyer区带毛细管电泳方法（capillary zone electrophoresis， CZE）研究了牛血清白蛋白与加替沙星分子间的结合作用机制.在位点结合模型的基础上，得到了实用的非线性模拟计算公式，在优选的实验条件下，根据模拟计算公式计算了蛋白质-药物相互作用的结合参数.
English
Characterization of Interaction between Gatifloxacin and Bovine Serum Albumin
Abstract:
The present study describes the application of capillary zone electrophoresis(CZE) to investigate the interaction between bovine serum albumin and gatifloxacin, the simplified method of Hummel-Dreyer was applied and the experimental condition was established after a large number of tests. Based on the site-binding model, practical formula for small ligand molecule to bio-macromolecule has been proposed; the binding parameters were measured according to suggested model by non-linear fitting program.
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